About: Monoclonal antibody to human chronic myeloid leukemia cell line MOLM-7 specifically reacts with an antigen of apoptotic cells.

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About: Monoclonal antibody to human chronic myeloid leukemia cell line MOLM-7 specifically reacts with an antigen of apoptotic cells. Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Monoclonal antibody 2E12 was prepared by immunization of mice with fresh cells of chronic myeloid leukemia cell line MOLM-7. Subset of cells of 15 tested cell lines and 10 cultured patients leukemic cells was positive with the 2E12 antibody. KG-1 and HL-60 cell lines were treated by camptothecin for 4 hours, washed and further cultivated up 48 hours. A significant increase of the positivity with 2E12 was detected after 24 and 48 hours of culture of both cell lines, which well correlated with the increase of mitochondial apoptotic antigen Apo 2.7 and with the subG1 peaks. The 2E12 positive cells were morphologically in the programmmed cell death, possibly apoptosis. It is suggested, that 2E12 antibody detects an antigen on apoptotic cells, which can be part of the signaling process for the ingestion by phagocytes. Monoclonal antibody 2E12 was prepared by immunization of mice with fresh cells of chronic myeloid leukemia cell line MOLM-7. Subset of cells of 15 tested cell lines and 10 cultured patients leukemic cells was positive with the 2E12 antibody. KG-1 and HL-60 cell lines were treated by camptothecin for 4 hours, washed and further cultivated up 48 hours. A significant increase of the positivity with 2E12 was detected after 24 and 48 hours of culture of both cell lines, which well correlated with the increase of mitochondial apoptotic antigen Apo 2.7 and with the subG1 peaks. The 2E12 positive cells were morphologically in the programmmed cell death, possibly apoptosis. It is suggested, that 2E12 antibody detects an antigen on apoptotic cells, which can be part of the signaling process for the ingestion by phagocytes. (en)
Title	Monoclonal antibody to human chronic myeloid leukemia cell line MOLM-7 specifically reacts with an antigen of apoptotic cells. Monoclonal antibody to human chronic myeloid leukemia cell line MOLM-7 specifically reacts with an antigen of apoptotic cells. (en)
skos:prefLabel	Monoclonal antibody to human chronic myeloid leukemia cell line MOLM-7 specifically reacts with an antigen of apoptotic cells. Monoclonal antibody to human chronic myeloid leukemia cell line MOLM-7 specifically reacts with an antigen of apoptotic cells. (en)
skos:notation	RIV/00023736:_____/02:00000070!RIV/2003/MZ0/L33003/N
http://linked.open.../vavai/riv/strany	45;54
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ00237360001)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Stöckbauer, Petr Hradcová, Martina Němcová, Jitka Marinov, Iuri
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	654232
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/02:00000070
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	monoclonal antibody; hematopoietic cell lines; apoptosis; camptothecin; Apo 2.7; necrosis (en)
http://linked.open.../riv/klicoveSlovo	camptothecin necrosis apoptosis monoclonal antibody hematopoietic cell lines Apo 2.7
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BDDC72CACF9A]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Marinov, Iuri Stöckbauer, Petr Němcová, Jitka Hradcová, Martina Novák, J. T.
http://linked.open...n/vavai/riv/zamer	Pathophysiology,diagnosis, and treatment of blood malignancies and blood coagulation disorders
issn	0145-2126
number of pages	10 (xsd:int)

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