About: Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells     Goto   Sponge   Distinct   Permalink

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  • Multipotent adult germ-line stem cells (maGSCs) and induced pluripotent stem cells (iPSCs) could be used to generate autologous cells for therapeutic purposes, which are expected to be tolerated by the recipient. However, effects of the immune system on these cells have not been investigated. In this study, we have compared the susceptibility of maGSC lines to IL-2-activated natural killer (NK) cells with embryonic stem cell (ESC) lines, iPSCs, and F9 teratocarcinoma cells. We found the pluripotent cells to be a very efficient target of syngeneic, allogeneic, and xenogeneic killer cells. The killing of pluripotent cell lines by syngeneic, allogeneic, and xenogeneic killer cells ranged between 48 and 265% in chromium release assays when compared to YAC-1 cells, which served as highly susceptible reference cells.
  • Multipotent adult germ-line stem cells (maGSCs) and induced pluripotent stem cells (iPSCs) could be used to generate autologous cells for therapeutic purposes, which are expected to be tolerated by the recipient. However, effects of the immune system on these cells have not been investigated. In this study, we have compared the susceptibility of maGSC lines to IL-2-activated natural killer (NK) cells with embryonic stem cell (ESC) lines, iPSCs, and F9 teratocarcinoma cells. We found the pluripotent cells to be a very efficient target of syngeneic, allogeneic, and xenogeneic killer cells. The killing of pluripotent cell lines by syngeneic, allogeneic, and xenogeneic killer cells ranged between 48 and 265% in chromium release assays when compared to YAC-1 cells, which served as highly susceptible reference cells. (en)
Title
  • Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells
  • Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells (en)
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  • Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells
  • Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells (en)
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  • RIV/00023728:_____/10:#0000018!RIV11-MZ0-00023728
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  • RIV/00023728:_____/10:#0000018
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  • multipotent adult germ-line stem cells; embryonic stem cells; teratomas; cellular cytotoxicity; NK receptor ligands (en)
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  • US - Spojené státy americké
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  • 24
http://linked.open...iv/tvurceVysledku
  • Novota, Peter
  • Dressel, R.
  • Elsner, L.
  • Engel, W.
  • Guan, K. M.
  • Hasenfuss, G.
  • Jaenisch, R.
  • Nolte, J.
  • Streckfuss-Bomeke, K.
http://linked.open...ain/vavai/riv/wos
  • 000279343600004
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  • 0892-6638
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