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| rdf:type
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| Description
| - Aktivita lipoproteinové lipázy (LPL) je zvýšena po umírněné konzumaci alkoholu a může přispívat ke zvýšené hladině HDL-cholesterolu, která hraje klíčovou úlohu v protektivním účinku alkoholu proti kardiovaskulárním onemocněním. Zvýšená hladina HDL-cholesterolu může být též způsobena tím, že alkohol stimuluje syntézu a sekreci apolipoproteinu A-I (apo A-I) v játrech. U samců myší C57BL/6 jsme proto testovali hypotézu, že konzumace alkoholu má vliv na expresi genů pro LPL a apo A-I (LPL a APOA1). Myši pily vodu nebo 5% alkohol a byly krmeny standardní laboratorní dietou nebo dietou vysokotukovou (HF) po dobu 4 týdnů. Exprese LPL byla stanovena v srdci, epididymální a dorsolumbální tukové tkáni, exprese APOA1 v játrech. Konzumace alkoholu neměla vliv na koncentraci lipidů a lipoproteinů v séru. Exprese LPL byla zvýšena v srdci myší pijících etanol na HF dietě ve srovnání s těmi na alkoholu a standardní dietě (p<0,001) a také v epididymálním tuku u myší pijících alkohol a krmených HF dietou proti myším (cs)
- The activity of lipoprotein lipase (LPL) is increased after alcohol consumption and can contribute to an increased level of HDL-cholesterol, which is considered to play a key role in the ethanol-mediated protective effect against cardiovascular disease. The increase in HDL-cholesterol concentration can be also due to an ethanol-enhanced synthesis and secretion of apolipoprotein A-I (apo A-I) from hepatocytes. Therefore, the hypothesis that ethanol consumption affects the LPL and apo A-I gene (LPL and APOA1, respectively) expression was tested in male C57BL/6 mice drinking 5 % ethanol or water and fed a standard chow or high-fat (HF) diet for 4 weeks. The LPL expression was determined in the heart, epididymal and dorsolumbal adipose tissues, the APOA1 expression in the liver. Alcohol consumption did not affect lipid and lipoprotein concentrations in the serum. The LPL expression was increased in the heart of mice given ethanol and HF diet compared to mice on chow and ethanol (p<0.001) and was also i
- The activity of lipoprotein lipase (LPL) is increased after alcohol consumption and can contribute to an increased level of HDL-cholesterol, which is considered to play a key role in the ethanol-mediated protective effect against cardiovascular disease. The increase in HDL-cholesterol concentration can be also due to an ethanol-enhanced synthesis and secretion of apolipoprotein A-I (apo A-I) from hepatocytes. Therefore, the hypothesis that ethanol consumption affects the LPL and apo A-I gene (LPL and APOA1, respectively) expression was tested in male C57BL/6 mice drinking 5 % ethanol or water and fed a standard chow or high-fat (HF) diet for 4 weeks. The LPL expression was determined in the heart, epididymal and dorsolumbal adipose tissues, the APOA1 expression in the liver. Alcohol consumption did not affect lipid and lipoprotein concentrations in the serum. The LPL expression was increased in the heart of mice given ethanol and HF diet compared to mice on chow and ethanol (p<0.001) and was also i (en)
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| Title
| - Ethanol consumption affects lipoprotein lipase gene expression in C57BL/6 mice
- Konzumace alkoholu ovlivňuje expresi genu pro lipoproteinovou lipázu u C57BL/6 myší (cs)
- Ethanol consumption affects lipoprotein lipase gene expression in C57BL/6 mice (en)
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| skos:prefLabel
| - Ethanol consumption affects lipoprotein lipase gene expression in C57BL/6 mice
- Konzumace alkoholu ovlivňuje expresi genu pro lipoproteinovou lipázu u C57BL/6 myší (cs)
- Ethanol consumption affects lipoprotein lipase gene expression in C57BL/6 mice (en)
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| skos:notation
| - RIV/00023001:_____/07:00000753!RIV08-MZ0-00023001
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/07:00000753
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - apolipoprotein A-I; lipoprotein lipase; ethanol consumption; gene expression; mouse (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kovář, Jan
- Mudráková, Eliška
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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