About: Instability of the genome of bone marrow cells of patients with AML and MDS.

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About: Instability of the genome of bone marrow cells of patients with AML and MDS. Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=OC10043
Description	The aim of our study in cooperation with COST projecBM0801 is to analyse chromosomal changes in complex karyotypes of patients with MDS and AML in detail using all molecular cytogenetic techniques which are available and to search for the new, so far non-described recurrent chromosomal changes. We wish to define the frequency and significance of these aberrations for disease progression and transformation of MDS into AML. As many rearrangements are cryptic and therefore their identification is possible by molecular-cytogenetic methods only, we will exploit modifications of FISH methods routinely used in our Center of Oncocytogenetics (FISH, I-FISH. mFISH, mBAND, CGH) and as the new approach we will start to use array CGH analyses. We will start pilot study with the specially designed chip for array CGH analyses of chromosome 5. We will also continue to search for rearrangments of MLL gene in myeloid malignancies to establish prognostic values in our cohort. We have very close co-operation with clin (en) Zjistit nenáhodnost vstupu chromosomů do přestaveb a rekurenci zlomových míst. Identifikovat geny spolupůsobící při progresi malignity a geny v oblastech s delecemi, zejména na chromosomu 5. Definovat skupiny pacientů vhodné pro individuální léčbu.
Title	Instability of the genome of bone marrow cells of patients with AML and MDS. (en) Nestabilita genomu buněk kostní dřeně nemocných s MDS a AML
skos:notation	OC10043
http://linked.open...avai/cep/aktivita	COST
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/OC10043/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/OC10043/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2013-06-28 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	92928016
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	AP - Aplikovaný výzkum
http://linked.open.../cep/klicovaSlova	genome instability in malignant cells chromosomal aberrations molecular cytogenetics myelodysplastic syndromes (MDS) acute myeloid leukemia (AML) (en)
http://linked.open...ep/partnetrHlavni	1. lékařská fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	7 (xsd:int)
http://linked.open...enychVysledkuVRIV	7 (xsd:int)
http://linked.open...lneniVMinulemRoce	2012-02-27 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/1081%2F2011-320
http://linked.open...iciPoslednihoRoku	2012
http://linked.open...atUdajeProjZameru	2013
http://linked.open.../vavai/cep/soutez	SMSM2010OC5
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2012-10-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	FD - Onkologie a hematologie
http://linked.open...ep/zahajeniReseni	2010-05-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Celogenomovou analýzou jsme u souboru nemocných s MDS/AML a komplexním karyotypem určili frekvenci rekurentních nebalancovaných aberací. Popsali jsme 375 zlomových míst lokalizovaných ve známých fragilních místech. Popsali jsme atypické delece 5q, které nezahrnovaly oblast CDR. Potvrdili jsme nestabilitu deletovaného chromosomu 5, který vstupuje do přestaveb s různými partnerskými chromosomy. (cs) By whole-genome analysis we determined the frequency of recurrent unbalanced aberrations in patients with MDS/AML and complex karyotype. We described 375 breakpoints located at known fragile sites as well as atypical 5q deletions that did not include the CDR. We confirmed substantial instability of d chromosome 5, often entering other rearrangements with various partner chromosomes. (en)
http://linked.open...tniCyklusProjektu	ZBKU
is http://linked.open...vavai/riv/projekt of	Changes associated with lenalidomide treatment in the gene expression profiles of patients with Del(5q) Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome Deletion of the long arm but not the 5q31 region of chromosome 5 in myeloid malignancies Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites A novel gene LRP5 on 11q13.2 is rearranged in two patients with acute myeloid leukemia From cryptic chromosomal lesions to pathologically relevant genes: Integration of SNP-array with gene expression profiling in myelodysplastic syndrome with normal karyotype
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10043/2010/orjk%3A11110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10043/2011/orjk%3A11110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10043/2012/orjk%3A11110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10043/2013/orjk%3A11110

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