About: Apoptosis in osteoarthritis: Investigation of the expression of apoptosi modulating molecules and the presence of cell death in OA joint tissues.     Goto   Sponge   Distinct   Permalink

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  • Synovium and bone could influence the cartilage degradation by producing cytokines or apoptosis incuding factors. We want to investigate the expression of apoptosis related molecules and the occurence of apoptosis. The experiments will be done with using methods such as immunohistochemistry (IHC), in situ hybridization, ELISA and siRNA. (en)
  • Synovie a kost se mohou produkcí cytokinů nebo faktorů způsobujících apoptózu podílet na degradaci chrupavky. Chtěli bychom zkoumat expresi a molekul spojených s apoptózou a výskyt apoptózy v OA synoviální membráně a chrupavce. Experimenty budou prováděny za použití metod imunohistochemie, in situ hybridizace, ELISA a siRNA.
Title
  • Apoptosis in osteoarthritis: Investigation of the expression of apoptosi modulating molecules and the presence of cell death in OA joint tissues. (en)
  • Osteoartritida a apoptóza: Exprese molekul ovlivňujících apoptózu ve vztahu k přítomnosti buněčné smrti v OA synoviální membráně a chrupavce.
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  • NR7907
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  • Osteoarthritis; apoptosis; synovium; cartilage (en)
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  • Zjištění antiapoptotické molekuly bcl2 a proapoptotických molekul bax, TRAIL a p53 v OA chrupavce. Apoptoza při OA může být způsobena extracelulárními stimuly, které mohou být produkovány synoviální membránou, kostí nebo samotnými OA chondrocyty. (cs)
  • Determ. of antiapoptotic molecule bcl2 and proapoptotic molecules bax, trail, p53 in OA cartilage. Apoptosis of chondrocytes in process of OA induced by extracell. stimuli as the molecules which can be produced by synovial membrane, bone or chondrocytes (en)
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  • Osteoarthritis
  • apoptosis
  • synovium
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