About: Genetic determination of humoral activation in chronic heart failure     Goto   Sponge   Distinct   Permalink

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Description
  • To find if there is an association between plasma levels of big endothelin, endothelin1 and clinical status and genetic polymorphisms -3A/-4A and G(8OOO)2A gene coding endothelin 1 in patients with chronic heart failure. To find, if there are associations between plasma levels of tumor necrosis factor alpha, clinical status and polymorphisms in gene coding TACE in patients with chronic heart failure. (en)
  • Zjistit, zda existují vztahy mezi plazmatickými hladinami big endotelinu, endotelinu1 a klinickým stavem a genetickýmí polymorfizmy -3A/-4A a G8OOO2A genu kódujícího endotelin 1 u pacientů s chronickým srdečním selháním. Zjistit, zda existují vztahy mezi hladinou tumor necrosis faktoru alfa, klinickým stavem a polymorfizmy genu TACE u pacientů s chronickým srdečním selháním.
Title
  • Genetic determination of humoral activation in chronic heart failure (en)
  • Genetické podklady humorální aktivace u chronického srdečního selhání
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  • NA7360
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  • Endothelin;Big endothelin;Gene polymorphisms;TNF alpha;Heart failure (en)
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  • Nenalezeny korelace mezi polymorfizmy genu pro endotelin-1 a jeho koncentrací v plazmě a mezi hladinou TNFalfa a polymorfizmy v genech. Hladiny působků jsou dány spíš hemodynamikou než genetikou. Alela A genotypu G8002A je spojena s rizikem komorbidit. (cs)
  • No correlation between plasma levels of endothelin-1 and gene polymorphisms and TNFalpha concentrations and polymorphisms founded. Humoral plasma levels are determined by hemodynamic not genetic. Allele A of genotype G8002A is bound with comorbidities. (en)
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  • TNF alpha
  • Endothelin
  • Big endothelin
  • Gene polymorphisms
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