About: Molecular and cellular principles of serious diseases

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=KSK2039602
Description	Projekt představuje koncentrované úsilí pracovníků několika biomedicinských ústavů AV ČR, zaměřené na objasnění molekulárních a buněčných mechanismů závažných chorob, jakými jsou nádorová onemocnění, AIDS, choroby srdce a cév, metabolická onemocnění, autoimunitní onemocnění a patologické stavy, vyvolané nepříznivými faktory zevního prostředí. Výsledky, které budou získány v kontextu světové vědy, přispějí nejen k poznání příčin těchto onemocnění, ale také k jejich racionální prevenci a kausální terapii. V projektu bude využito všech dostupných metodických přístupů molekulární a buněčné biologie. Předpokládáme využití unikátních nálezů, získaných při řešení projektu, pro rozvoj moderní české mediciny. The project %22Molecular and cellular principles of serious diseases%22 represents the concerted action of researchers from several biomedical institutes of the ASCR, oriented towards the investigation of the molecular and cellular mechanisms of serious diseases such as cancers, AIDS, cardiovascular, metabolic and autoimmune diseases, and pathological states caused by adverse environmental factors. The results that will be obtained, together with findings from the international scientific community, will contribute not only to an understanding of the etiology and mechanism of these diseases, but also to their prevention and therapy. In this project, we will employ all available methods of molecular and cellular biology. We anticipate that unique findings obtained in these studies will be utilized for the future development of modern Czech medicine. (en)
Title	Molecular and cellular principles of serious diseases (en) Molekulární a buněčné základy závažných onemocnění
skos:notation	KSK2039602
http://linked.open...avai/cep/aktivita	Scheme of the development of investigative research in key branches of science
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/KSK2039602/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/KSK2039602/celkoveNaklady
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	600627
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...ep/partnetrHlavni	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	45 (xsd:int)
http://linked.open...enychVysledkuVRIV	45 (xsd:int)
http://linked.open...iciPoslednihoRoku	2001
http://linked.open...atUdajeProjZameru	2001
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	EA - Morfologické obory a cytologie
http://linked.open...jektu+dodavatelem	Byla získána řada pozoruhodných výsledků v oblasti objasňování molekulárních a buněčných mechanizmů vybraných závažných onemocnění, zejména nádorových a civilizačních chorob. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
is http://linked.open...vavai/riv/projekt of	Chromosomes participating in translocations typical of malignant hemoblastoses are also involved in exchange aberrations induced by fast neutrons Convergent evolution of cytokines. Diffusion Barriers Evoked in the Rat Cortex by Reactive Astrogliosis. Pretreatment with granulocyte colony-stimulating factor reduces myelopoiesis in irradiated mice Protective Effects of Type I and Type II Interferons toward Rous Sarcoma Virus-Induced Tumors in Chickens. Tight binding of bulky fluorescent derivatives of adenosine to the low affinity E2ATP site leads to inhibition of Na+/K+-ATPase. Volume transmission in the CNS and its relevance for neuropsychopharmacology. Contribution of autosomal loci and the Y chromosome to the stress response in rats. Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat. Immunocompatibility and biocompatibility of cell delivery systems. Genetic analysis of rat chromosome 1 and the Sa gene in spontaneous hypertension. Influence of Cell Fixation on Chromatin Topography. Extracellular space diffusion and pathological states. Glial diffusion barriers during aging and pathological states. Human DNA adducts of 1,3 - butadiene, an important environmental carcinogen. Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitopes and of the region mediating cell adhesion. Mapping of quantitative trait loci (QTL) of differential stress gene expression in rat recombinant inbred strains. Radioprotective Action of Extracellular Adenosine on Bone Marrow Cells in Mice Exposed to Gamma Rays as Assayed by the Micronucleus Test. Use of co-loaded Fluo-3 and fura red fluorescent indicators for studying the cytosolic Ca2+ concentrations distribution in living plant tissue. TNF-alfa modulates the differentiation induced by butyrate in the HT-29 human colon adenocarcinoma cell line. Temporal in vitro expansion of the luminal lineage of human mammary epithelial cells achieved with the 3T3 feeder layer technique. A possibility to overcome P-glycoprotein (PGP)-mediated multidrug resistance by antibody-targeted drugs conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier. A novel deficiency of mitochondrial ATPase of nuclear origin. Astrocytes, oligodendroglia, extracellular space volume and geometry in rat fetal brain grafts. Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised by antigliadin antibodies of patients with coeliac disease. Identification of Cd36(Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat. Glial swelling and astrogliosis produce diffusion barriers in the rat spinal cord. Inhibition of the Rous Sarcoma Virus Long Terminal Repeat-Driven Transcription by in Vitro Methylation: Different Sensitivity in Permissive Chicken Cells versus Mammalian Cells. Ontogenetic aspects of hypertension development: Analysis in the rat. Activation of macrophages by food antigens:enhancing effect of gluten on nitric oxide and cytokine production. Antiproliferative effect of a lectin- and anti-Thy-1.2 antibody-targeted HPMA copolymer-bound doxorubicin on primary and metastatic human colorectal carcinoma and on human colorectal carcinoma transfected with the mouse Thy-1.2 gene. A novel principle for conferring selectivity to poly(A)-binding proteins:interdependence of two ATP synthase beta-subunit mPNA-binding proteins. Effects of fluorenscent pseudo-ATP and ATP-metal analogs on secondary structure of Na+/K+-ATPase. Decreased fatty acid synthessis due to mitochondrial uncoupling in adipose tissue. Effect of labeling of plasma lipoproteins with /3H/cholesterol on values of esterification rate of cholesterol in apolipoprotein B-deplated plasma. Development of intestinal transport function in mammals. Different expression of some molecular markers in sporadic cancer of the left and right colon. Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis. Influence of the joint treatment with granulocyte colony-stimulating factor and drugs elevating extracellular adenosine on erythropoietic recovery following 5-fluorouracil-induced haematotoxicity in mice. Long distance signalling in volume transmission. Focus on clearance mechanism. Link between a novel human .tau.D-crystallin allele and a unique cataract phenotype explained by protein crystallography. Local cytokine therapy of cancer: Interleukin-2, interferons and related cytokines. Occurrence of IgA and IgG autoantibodies to calreticulin in coeliac disease and various autoimmune diseases. Nuclear tolography of the c-myc gene in human leukemic cells.
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