About: Phosphorylation-mediated signalling in DNA damage response and cancer     Goto   Sponge   Distinct   Permalink

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  • In this application we will investigate the following five aims: Aim I) Molecular mechanism of PPM1D/Wip1 phosphatase function in DDR Aim II) Role of truncating PPM1D mutations in colorectal cancer Aim III) Functional role of PP1 phosphatase in DNA damage checkpoints and repair Aim IV) Novel role of ATR-Chk1-Aurora-A signalling in Fanconi anemia pathway (en)
  • In this application we will investigate the following five aims: Aim I) Molecular mechanism of PPM1D/Wip1 phosphatase function in DDR Aim II) Role of truncating PPM1D mutations in colorectal cancer Aim III) Functional role of PP1 phosphatase in DNA damage checkpoints and repair Aim IV) Novel role of ATR-Chk1-Aurora-A signalling in Fanconi anemia pathway Aim V) Molecular mechanism of Cdc7 kinase-dependent replisome stabilization
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  • Phosphorylation-mediated signalling in DNA damage response and cancer
  • Phosphorylation-mediated signalling in DNA damage response and cancer (en)
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  • 7F14061
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  • DNA damage response; Phosphorylation; protein phosphatase; cancer; cell cycle; checkpoint; irradiation; genome integrity; protein kinase; replication stress (en)
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  • DNA damage response
  • cancer
  • cell cycle
  • checkpoint
  • irradiation
  • protein kinase
  • Phosphorylation
  • genome integrity
  • protein phosphatase
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