About: Desing of a vaccine to immunize neonates against GBS infections through a durable maternal immune response

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=7E08043
Description	Direct vaccination cannot prevent diseases that affect neonates in the first days of live. Group B Streptococcus (GBS) is the major cause of neonatal septicemia nd meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that high titres of maternal antibody to GBS capsular polysaccharides (CPS) correlate with reduced risk of diseases in neonates suggesting that maternal immunization may be an effective strategy for delivery of a protective immune response to the child in this early period. The overall objective of this proposal is to design immunization strategies capable of inducing strong durable and placentally transferable protective immune responses agains GBS in women in order to fill this gap in early infancy when direct immunization is not possible.Starting with the genome sequenceof 8 strains of GBS, Novartis scientist (en) Direct vaccination cannot prevent diseases that affect neonates in the first days of live. Group B Streptococcus (GBS) is the major cause of neonatal septicemia nd meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that high titres of maternal antibody to GBS capsular polysaccharides (CPS) correlate with reduced risk of diseases in neonates suggesting that maternal immunization may be an effective strategy for delivery of a protective immune response to the child in this early period. The overall objective of this proposal is to design immunization strategies capable of inducing strong durable and placentally transferable protective immune responses agains GBS in women in order to fill this gap in early infancy when direct immunization is not possible.Starting with the genome sequenceof 8 strains of GBS, Novartis scientist
Title	Desing of a vaccine to immunize neonates against GBS infections through a durable maternal immune response (en) Desing of a vaccine to immunize neonates against GBS infections through a durable maternal immune response
skos:notation	7E08043
http://linked.open...avai/cep/aktivita	Subvention of the projects of the Seventh Framework Programme of the European Community for research, technological development including demonstration activities (FP7) according to the Czech law 171/2007 Sb.
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/7E08043/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/7E08043/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2011-06-30 (xsd:date)
http://linked.open...i/cep/druhSouteze	RP - Spolufinancování programu ES
http://linked.open...ep/duvernostUdaju	C - Předmět podléhá obchodnímu tajemství (§17 až 20 Obchodního zákoníku), ale některé údaje jsou upraveny tak, aby byly zveřejnitelné
http://linked.open.../cep/fazeProjektu	82558806
http://linked.open...ai/cep/hlavniObor	FN - Epidemiologie, infekční nemoci a klinická imunologie
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open...vai/cep/kategorie	AP - Aplikovaný výzkum
http://linked.open.../cep/klicovaSlova	Vaccine; GBS; Streptococcos; Newborns; Passive immunisations (en)
http://linked.open...ep/partnetrHlavni	Státní zdravotní ústav
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	2 (xsd:int)
http://linked.open...enychVysledkuVRIV	2 (xsd:int)
http://linked.open...lneniVMinulemRoce	2010-04-27 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/3094%2F2010-32
http://linked.open...iciPoslednihoRoku	2010
http://linked.open...atUdajeProjZameru	2011
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2010-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	EC - Imunologie EE - Mikrobiologie, virologie
http://linked.open...ep/zahajeniReseni	2008-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Hodnocení výsledků řešení ministerstvo neprovádí, neboť podmínkou podpory je, že uchazeč byl vybrán mezinárodním poskytovatelem v souladu s pravidly příslušného programu. Projekt je hodnocen až po jeho schválení mezinárodním poskytovatelem. (cs) Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider (en)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open...n/vavai/cep/vyzva	http://linked.opendata.cz/resource/domain/vavai/cep/vyzva/FP7-HEALTH-2007-A
http://linked.open.../cep/klicoveSlovo	Vaccine GBS Newborns Streptococcos
is http://linked.open...vavai/riv/projekt of	International external quality assurance for laboratory identification and typing of Streptococcus agalactiae (group B Streptococci) Prevention of group B streptococcal neonatal disease revisited. The DEVANI European project
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E08043/2008/ico%3A75010330 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E08043/2009/ico%3A75010330 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E08043/2010/ico%3A75010330 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E08043/2011/ico%3A75010330

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