Cílem projektu je vybrat vhodné kmeny Salmonella enterica pro vakcinaci, ověřit jejich vlastnosti na kuřatech a sestavit vakcinační schéma, které by chránilo drůbež proti 3 nejčastěji se vyskytujícím serovarům (Enteritidis, Typhimurium a Infantis) v ČR. (cs)
The projekt will be focused on the characterisation of live attenuated strains of Salmonella enterica serovar Enteritidis, Typhimurium and Infantis. In the first part of the project, suitable representative strains of each serovar will be selected. Next, individual constructed mutants will be tested for their attenuation and immunogenicity in chickens. Finally, different vaccination schemes based on immunisation with attenuated strain of different serovars will be tested. This should result into a knowledge of a vaccine potential ready for additional clinical studies aiming at the production of a vaccine protecting poultry against infection with S. Enteritidis, S. Typhimurium and S. Infantis. (en)