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  • V mozkomíšním moku a séru pacientů s AN a bez ní budou ELISA metodami stanoveny hladiny neurocytoskeletálních proteinů (protein tau, fosfotau, lehká a těžká podjednotka neurofilamentového tripletu) a současně protilátky proti nim. Hladina samotných proteinů, protilátek proti nim a především jejich vzájemná interakce mohou přispět k popisu odlišností mezi patologickým a fyziologickým stárnutím mozku. Výsledkem řešení projektu by mohlo být zkvalitnění klinické diagnostiky AN a zjištění nových poznatků u AN z hlediska humorální imunity. (cs)
  • Neurocytoskeletal proteins (tau and phosphotau proteins, light and heavy subunits of neurofilaments) and antibodies against them will be measured using ELISA in samples of cerebrospinal fluid and serum in patients with and without Alzheimer´s disease. Levels of neurocytoskeletal proteins themselves, antibodies against these proteins themselves and especially their mutual relationship may contribute to the differences between pathological and physiological ageing of the brain. The outcome of the project could be refining the diagnosis of AD and find new immunological aspects of AD in terms of humoral immunity. (en)
Title
  • Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer´s disease (en)
  • Využití neurocytoskeletálních proteinů a protilátek proti nim v diagnostice Alzheimerovy nemoci (cs)
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  • Alzheimer´s disease; cerebrospinal fluid; biomarker; neurofilament; antibody; diagnosis; tau; phosphotau; beta amyloid; neuronal cytoskeleton (en)
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