About: Analysis of intracellular IL-1RA isoforms in patients with juvenile idiopathic arthritis and their relation to clinical features of the disease     Goto   Sponge   Distinct   Permalink

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  • Differentiation of production of IL-1RA izoforms in cell populations in peripheral blood/synovial tissue of JIA patients and peripheral blood of controls. Correlation of expression profile with clinical parameters and disease activity of JIA and IL-1RN*1/1, IL-1RN*1/2 a IL-1RN*2/2 genotypes in JIA patients and controls Conclusions deduced from the results could suggest whether icIL-1RA izoforms actively participates in the maintenance of IL-1/IL-1RA balance, whether their activity is limited to particular immune compartment, cell type or JIA subgroup (en)
  • Diferenciace produkce intracelulárních isoforem IL-1RA v buněčných populacích periferní krve/synoviální tkáně pacientů s JIA a periferní krve kontrol Korelace expresního profilu s klinickými parametry a aktivitou JIA a IL-1RN*1/1, IL-1RN*1/2 a IL-1RN*2/2 genotypy pacientů s JIA a kontrol. Vliv anti-TNF terapie na produkci intracelulárních forem IL-1RA. Závěry vyvozené z výsledků by mohly objasnit, zda se icIL-1RA izoformy účastní udržování IL-1/IL-1RA rovnováhy aktivně, zda je jejich aktivita omezena na určitý imunologický kompartment, buněčný typ nebo podskupinu JIA. (cs)
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  • Analysis of intracellular IL-1RA isoforms in patients with juvenile idiopathic arthritis and their relation to clinical features of the disease (en)
  • Analýza intracelulárních forem IL-1RA u pacietů s juvenilní revmatoidní artritidou a jejich vztah ke klinickým charakteristikám choroby (cs)
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  • juvenile; IL-1; IL-1/IL-RA; real-time; arthritis; IL-1RA; balance; PCR (en)
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