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  • The effect of alcohol consumption on expression of genes involved in regulation of lipoprotein metabolism (apolipoprotein A-I, ABC A1 transporter, lipoprotein lipase) will be studied in C57BL/6 mice. The role of genetic predisposition to hypertriglyceridemia in response of triglyceride-rich lipoprotein metabolism to alcohol consumption will be studied in hereditary hypertriglyceridemic (HTG) rats. The effect of alcohol consumption on HDL cholesterol and atherosclerosis progression and modulation of such an effect by dietary fat intake will be studied in apolipoprotein E knockout mice. (en)
  • Na C57BL/6 myších bude zjišťováno, zda má konzumace alkoholu vliv na expresi vybraných genů zapojených v regulaci metabolismu lipoproteinů (apolipoprotein A-I, ABC A1 transportér, lipoproteinová lipáza). Na hereditárně hypertriglyceridemických (HTG) potkanech bude zjišťováno, zda genetická predispozice k hypertriacylglycerolémii ovlivňuje odpověď lipoproteinového metabolismu - lipoproteinů transportujících triacylglyceroly - na konzumaci alkoholu. Na apo E KO myších bude ověřováno, zda konzumace alkoholu příznivě ovlivňuje koncentraci HDL a progresi aterosklerózy a zda je takový efekt modulován množstvím tuku v dietě. (cs)
Title
  • Alcohol and regulation of lipoprotein metabolism (en)
  • Alkohol a regulace metabolismu lipoproteinů (cs)
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  • alcohol; HDL; triglyceride; lipoprotein lipase; apolipoprotein A-I; ABC A1 transporter; mouse; rat (en)
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