About: The novel molecular biology methods in early diagnosis of acute and chronic rejection. Determination of gene expression within rejecting renal allografts.     Goto   Sponge   Distinct   Permalink

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  • Diagnosis of acute and chronic rejection of renal allograft using IL-6, IL-10, TNF-alpha, TGF-beta, RANTES, MCP-1 and CD3 gene expression (RT-PCR in real time) in kidney tissue. Observation of effect of polymorphisms in TNF-alpha, TGF-beta1, IL-6 and IL-10 genes on development of acute and chronic rejection after renal transplantation and on gene expression in renal tissue. Observation of influence of TNF-alfa, TGF-beta, IL-6 and IL-10 cytokine genotypes of both recipients and donors of renal allografts and their combination on development of acute and chronic rejection after renal transplantation. (en)
  • Diagnostika akutní a chronické rejekce renálního štěpu pomocí exprese genů pro IL-6, IL-10, TNF-alfa, TGF-beta, CD-3, RANTES, MCP-1 v ledvinné tkáni Sledování vlivu polymorfismu genů pro TNF-alfa, TGF-beta, Il-6 a Il-10 na rozvoj akutní a chronické rejekce po transplantaci ledviny a na expresi sledovaných genů v ledvinné tkáni. Sledování vlivu kombinace polymorfismu genů pro TNF-alfa, TGF-beta1, Il-6 a Il-10 u dárce a příjemce ledvinného štěpu na rozvoj akutní a chronické rejekce po transplantaci a na expresi sledovaných genů v ledvinné tkáni. (cs)
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  • The novel molecular biology methods in early diagnosis of acute and chronic rejection. Determination of gene expression within rejecting renal allografts. (en)
  • Časná diagnostika akutní a chronické rejekce pomocí molekulárně biologických metod. Stanovení exprese genů v ledvinné tkáni v průběhu rejekce renálního štěpu. (cs)
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  • gene expression;gene polymorphism;acute rejection;chronic rejection;kidney transplantation;cytokines;chemokines (en)
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