About: The influence of fibrates on homocystein metabolism and its impact on endothelial dysfunction and coagulation status in dyslipidemic patients.     Goto   Sponge   Distinct   Permalink

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  • Stanovení vlivu léčby fibráty na hladiny homocysteinu ve srovnání s léčbou statiny. Dopad interakce léčby fibráty s metabolismem homocysteinu na parametry endoteliální dysfunkce a koagulační status pacientů ve srovnání s léčbou statiny. Možnosti léčebného ovlivnění interakce fibrátů s metabolismem homocysteinu pomocí vitaminové substituce a dopad na parametry endoteliální dysfunkce a koagulace, stanovení potencionálního vlivu genetického polymorfismu enzymu MTHFR. Srovnání účinku statinů a fibrátů na parametry endotheliální dysfunkce a koagulace, srovnání dvou dávkovacích režimů statinů a stanovení korelace mezi hypolipidemickým a non-cholesterolovým účinkem statinů. (cs)
  • To establish the impact of fibrate treatment in comparison with statins on plasma homocystein levels. To establish the impact of interaction of fibrate treatment and metabilism of homocystein on endothelial dysfunction and coagulation status in comparison with statins. To study the potential to influence the hyperhomocysteinemia induced by fibrates with vitamine substitution and to establish the impact on endothelial dysfunction and coagulation, in relationship to infdividual genetic polymorphism of MTHFR. To compare the effect of statins with fibrates on endothelial dysfunction and coagulation factors, with regard to its hypolipidemical and non-cholesterol dependent effect of both drugs. (en)
Title
  • Vliv fibrátů na metabolismus homocysteinu a klinický dopad na markery endotheliální dysfunkce a koagulace u dislipidemickýchpacientů. (cs)
  • The influence of fibrates on homocystein metabolism and its impact on endothelial dysfunction and coagulation status in dyslipidemic patients. (en)
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  • Homocystein;Fibrates;Statins;Coagulation;Endotelial dysfunction;Folates (en)
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