About: Pharmacological therapy of endocrine and metabolic abnormalities of the polycystic ovary syndrome (PCOS).     Goto   Sponge   Distinct   Permalink

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  • Práce se zabývá možnostmi dlouhodobého ovlivnění endokrinních a metabolických abnormalit syndromu polycystických vaječníků (PCOS). Cílem projektu je zjistit vliv přípravku hormonální antikoncepce s obsahem nízce androgenního progestinu v monoterapii nebo v kombinaci s metforminem na syntézu androgenů, na lipidové spektrum a na periferní insulinovou sensitivitu. Na základě výsledků bude doporučena optimální intervence, vhodná k dlouhodobé léčbě pacientek s PCOS. (cs)
  • The project addresses the possibilities of long-term modulation of endocrine and metabolic abnormalities of the polycystic ovary syndrome (PCOS). The aim of the project is to establish the effect of a hormonal contraceptive containing a low-androgenic progestin in monotherapy or in combination with metformine on androgen synthesis, lipid spectrum, and on the peripheral insulin sensitivity. (en)
Title
  • Pharmacological therapy of endocrine and metabolic abnormalities of the polycystic ovary syndrome (PCOS). (en)
  • Farmakologická léčba endokrinních a metabolických abnormalit syndromu polycystických vaječníků (PCOS - polycystic ovary syndrome) (cs)
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  • PCOS;hyperandrogenemia;insulin resistance;hormonal contraceptives;metformin;clamp (en)
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