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  • To determine the diagnostic approach of the Barrett´s oesophagus. To arrange the optimal number of endoscopic examinations after the positive diagnosis. To determine the quantification method of histologically confirmed dysplasias. To determine retrospectively relation between duration of exposition and amount of reflux liquid and occurring of metaplasia To learn about genetic changes participating on conception of BO and estimate possible genetic cause of carcinoma occurring in BO To determine influence of antireflux treatment and surgical procedures to development of metaplasias to regression or progresion of disease To confront conservative and surgical treatments To compare ablation therapy with other methods and its effect. To examine patients by endoscopic and bioptic methods, periodically, during different treatment management and work up statistically effect of treatment method to development of disease. To determine optimal treatment management for patients with the BO. (en)
  • Stanovit postup diagnostiky Barrettova jícnu. Určit optimální četnost endoskopických kontrol po stanovení diagnozy. Stanovit metodu kvantifikace histologicky ověřených dysplazií. Retrospektivně stanovit souvislost délky expozice a množství refluktátu na vznik metaplazie. Stanovit genetické změny při vzniku Barrettova jícnu a určit možnou genetickou závislost na vznik karcinomu v Barrettově jícnu. Zjistit vliv antirefluxní léčby a operací na vývoj metaplazií, na regresi event. progresi onemocnění. Porovnat konzervativní léčbu s operační. Porovnat metodu ablační terapie s ostatními typy léčby a její vliv na vznik karcinomu. Endoskopicky a biopticky sledovat pacienty v pravidelných intervalech při různých léčebných metodách a statisticky vyhodnocovat vliv léčby na vývoj onemocnění. Stanovit optimální léčbu pacientů s Barrettovým jícnem. (cs)
Title
  • Komplexní léčba Barrettova jícnu (cs)
  • New modalities in treatment of Barrett´s oesophagus (en)
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  • Barrett´s oesophagus;Reflux;metaplasia;oesophageal carcinoma;antireflux surgical procedure;Endoscopy;ablation therapy;oesophageal resection (en)
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