About: Effect of change in sex hormons concentrations on insulin action     Goto   Sponge   Distinct   Permalink

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  • To investigate changes in insulin action by euglycaemic clamp technique in hyperandrogenic men, hyperandrogenic women, women with PCOS and postmenopausal women. To establish whether obesity is the main predictor of insulin resistance in PCOS women. To investigate the influence of causal therapy of hypoandrogenism with Undestor, hyperandrogenism with Androcur, PCOS with Cilest and postmenopausal osteoporosis with Klimonorm. (en)
  • Zjistit změny působení inzulínu isoglykemických clampem u hypoandrogenních mužů, hyperandrogenních žen, u žen se syndromem polycystických ovarií a postklimakterických žen s osteoporózou. Zjistit, zdali u žen se syndromem polycystických ovárií není hlavním prediktorem inzulínové rezistence obezita. Zjistit ovlivnění působení inzulínu léčbou hypoandrogenismu mužů Undestorem, hyperandrogenismu žen Androcurem, PCOS Cilestem a postklimakterických žen s osteoporózou Klimonormem. Zjistit vztah charakteristik působení inzulínu ke koncentraci některých IGF-1 vazebných proteinů BP-1, BP-3 a rovněž SHBG. (cs)
Title
  • Effect of change in sex hormons concentrations on insulin action (en)
  • Vliv změn koncentrací pohlavních hormonů na působení inzulínu. (cs)
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  • insulin resistence; hypoandrogenismus; hyperandrogenismus; polycystic ovarial syndrome; postclimacteric women; clamp; binding proteins (en)
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