About: Strategy of oral immunization: significance for systemic and mucosal immunity and use for prevention and therapy

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About: Strategy of oral immunization: significance for systemic and mucosal immunity and use for prevention and therapy Goto Sponge Distinct Permalink

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Description	Budou sledovány možnosti ovlivnění systémové a slizniční imunity po orální imunizaci. Bude testován účinek různých adjuvancií, nosičů a vektorů: Bacillus firmus jako adjuvans a nosič (ervent. vektor), mutanta Escherichia coli 083 K24 H31 hlyA- jako živý vektor, adenylát-cyklázový é mechanismy uplatňující se při patogeneze celiakie. Výsledky mohou být využitelné pro rozvoj nových vakcinačních strategií. (cs) Possibilities of modulation of mucosal and systemic immunity after oral immunization will be studied. The effect of various adjuvants, carriers and vectors on induction of protective immunity or oral tolerance will be tested. Bacillus firmus has strong immunomodulatory activities and will be used as adjuvant and antigen carrier. A mutant of E. coli O83 K24 H31 hlyA- with excellent intestine colonizing properties will be used as live vector for tetanic toxin. Effectiveness of adenylate-cyclase toxin (ACT) of Bordetella pertussis as a constituent of subunit vaccine against pertussis will be followed. Integration of various heterologous epitopes into ACT can influence their presentation to lymphocytes and character of immune response. Chimeric ACT with gliadin epitopes will be exploited in the study of antigen presentation and its significance for pathogeny of celiac disease. The results expected could be used (en)
Title	Strategy of oral immunization: significance for systemic and mucosal immunity and use for prevention and therapy (en) Strategie orální imunizace, její výzkum pro systémovou a slizniční imunitu a využití k preventivním a léčebným účelům (cs)
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http://linked.open...vai/klicova-slova	mucosal immunity; peroral immunization; oral tolerance; mucosal adjuvants; antigen carriers; mucosal (en)
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