About: Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis     Goto   Sponge   Distinct   Permalink

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  • "Cˇlem projektu Voln‚ lehk‚ ýetŘzce imunoglobulin… v˙likvoru, s‚ru a moźi u roztrouçen‚ skler˘zy je 1) ovŘýit na rozs hlejçˇm souboru cca 150 pacient… věznam stanovenˇ volněch lehkěch ýetŘzc… imunoglobulin… (fLC) v˙likvoru v˙diagnostice roztrouçen‚ skler˘zy (RS), 2) vysledovat vztahy mezi koncentracemi fLC v˙likvoru, s‚ru a moźi (pýˇpadnŘ t‚§ poźtem oligoklon lnˇch fLC p s… v˙likvoru) a a) věsledky ostatnˇch vyçetýenˇ likvoru bاnŘ prov dŘněch u pacient… s˙RS, b) klinickěmi parametry, zejm‚na aktivitou onemocnŘnˇ a tˇ§ˇ posti§enˇ, 3) sledovat dynamiku koncentracˇ fLC (pýˇpadnŘ t‚§ oligoklon lnˇho vzorce fLC v˙likvoru) u jednotlivěch pacient… v˙z vislosti na klinick‚m stavu, MRI n lezu a pou§it‚ l‚źbŘ, pýedevçˇm u pacient… pýed/po transplantacautolognˇch hematopoetickěch kmenověch bunŘk, 4) pr…bاnŘ zdokonalovat kvantitativnˇ i kvalitativnˇ metody vyçetýenˇ fLC, zejm‚na zvěçit senzitivitu pr…kazu fLC metodou izoelektrick‚ fokusace s˙n sledněm imunoblottingem, aby bylo mo§n‚ posoudit ""norm lnˇ" (cs)
  • The goals of the project Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis are as follows: 1) to confirm the significance of the determination of free light chains of immunoglobulins (fLC) in cerebrospinalfluid (CSF) in the diagnosis of multiple sclerosis (MS) in a larger series of about 150 patients, 2) to evaluate possible relationships between fLC concentrations in CSF, serum and urine (and, possibly, also the number of fLC bands in CSF) and between a)the results of other CSF tests performed routinely in samples from MS patients, b) clinical parameters, mainly disease activity and degree of disability, 3) to assess the dynamics of fLC concentrations in the above mentioned biological fluids (and, possibly, also of oligoclonal fLC pattern in CSF) in individual MS patients according to their clinical status, MRI findings, and treatment, especially in patients before/after autologous hematopoietic stem cell transplantation, 4) to improve both (en)
Title
  • Voln‚ lehk‚ ýetŘzce imunoglobulin… v likvoru, s‚ru a moźi u roztrouçen‚ skler˘zy (cs)
  • Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis (en)
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