About: The role of ABC transporters in progression and clinical outcome of colorectal cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role in the development of resistance by the efflux of anticancer agents outside of cancer cells. The aim of this study was to explore transcript levels of all human ABCs in tumours and non-neoplastic control tissues from CRC patients collected before the first line of treatment by 5-fluorouracil (5-FU)-containing regimen. The prognostic potential of ABCs was evaluated by the correlation of transcript levels with clinical factors. Relations between transcript levels of ABCs in tumours and chemotherapy efficacy were also addressed. The transcript profile of all known human ABCs was assessed using real-time polymerase chain reaction with a relative standard curve. The majority. Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role in the development of resistance by the efflux of anticancer agents outside of cancer cells. The aim of this study was to explore transcript levels of all human ABCs in tumours and non-neoplastic control tissues from CRC patients collected before the first line of treatment by 5-fluorouracil (5-FU)-containing regimen. The prognostic potential of ABCs was evaluated by the correlation of transcript levels with clinical factors. Relations between transcript levels of ABCs in tumours and chemotherapy efficacy were also addressed. The transcript profile of all known human ABCs was assessed using real-time polymerase chain reaction with a relative standard curve. The majority. (en)
Title	The role of ABC transporters in progression and clinical outcome of colorectal cancer The role of ABC transporters in progression and clinical outcome of colorectal cancer (en)
skos:prefLabel	The role of ABC transporters in progression and clinical outcome of colorectal cancer The role of ABC transporters in progression and clinical outcome of colorectal cancer (en)
skos:notation	RIV/75010330:_____/12:00009720!RIV13-GA0-75010330
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA310/07/1430), P(NS10230), S, Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Souček, Pavel Hlavatá, Ivona Václavíková, Radka Mohelníková-Duchoňová, Beatrice
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní zdravotní ústav, příspěvková organizace
http://linked.open...dnocenehoVysledku	165963
http://linked.open...ai/riv/idVysledku	RIV/75010330:_____/12:00009720
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; ABC transporters (en)
http://linked.open.../riv/klicoveSlovo	ABC transporters colorectal cancer
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[977EA6FB6A2E]
http://linked.open...i/riv/nazevZdroje	Mutagenesis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic. Rationalization of strategy of oncological treatment of radically inoperable colorectal liver metastases
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Souček, Pavel Novák, P. Třeška, V. Václavíková, Radka Hlavatá, Ivona Vodička, P. Liška, V. Mohelníková-Duchoňová, Beatrice Holubec, L. Bruha, J. Piťule, P. Vyčítal, O.
http://linked.open...ain/vavai/riv/wos	000300040200007
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0267-8357
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/mutage/ger075

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