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  • This paper discusses the contribution of NCX to the pathological pattern of intracellular calcium regulation and contraction on the basis of computer simulations of a virtual cell. The model comprises calcium handling mechanisms, troponin control and acto-myosin interactions. The contribution of NCX was studied by changing its activity and turning it off for some simulations.It was found that NCX helps to support diastolic function by reducing the Ca2+ level during the diastole. At the same time there is a reduction in peak Cai and hence contraction.
  • This paper discusses the contribution of NCX to the pathological pattern of intracellular calcium regulation and contraction on the basis of computer simulations of a virtual cell. The model comprises calcium handling mechanisms, troponin control and acto-myosin interactions. The contribution of NCX was studied by changing its activity and turning it off for some simulations.It was found that NCX helps to support diastolic function by reducing the Ca2+ level during the diastole. At the same time there is a reduction in peak Cai and hence contraction. (en)
Title
  • Computer insight into the molecular level of heart failure. What is the role of NCX?
  • Computer insight into the molecular level of heart failure. What is the role of NCX? (en)
skos:prefLabel
  • Computer insight into the molecular level of heart failure. What is the role of NCX?
  • Computer insight into the molecular level of heart failure. What is the role of NCX? (en)
skos:notation
  • RIV/68407700:21220/08:00147964!RIV11-MSM-21220___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6840770012)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 360894
http://linked.open...ai/riv/idVysledku
  • RIV/68407700:21220/08:00147964
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • NCX; calcium; heart failure; numerical models (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [DEFEEE5DBC39]
http://linked.open...i/riv/nazevZdroje
  • Acta Polytechnica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 48
http://linked.open...iv/tvurceVysledku
  • Konvičková, Svatava
  • Kittnar, O.
  • Mlček, M.
  • Fischer, Martin
http://linked.open...n/vavai/riv/zamer
issn
  • 1210-2709
number of pages
http://localhost/t...ganizacniJednotka
  • 21220
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