About: ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

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About: ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence that ATR activity at the nuclear envelope responds to mechanical stress. Human ATR associates with the nuclear envelope during S phase and prophase, and both osmotic stress and mechanical stretching relocalize ATR to nuclear membranes throughout the cell cycle. The ATR-mediated mechanical response occurs within the range of physiological forces, is reversible, and is independent of DNA damage signaling. ATR-defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown. We propose that mechanical forces derived from chromosome dynamics and torsional stress on nuclear membranes activate ATR to modulate nuclear envelope plasticity and chromatin association to the nuclear envelope, thus enabling cells to cope with the mechanical strain imposed by these molecular processes. ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence that ATR activity at the nuclear envelope responds to mechanical stress. Human ATR associates with the nuclear envelope during S phase and prophase, and both osmotic stress and mechanical stretching relocalize ATR to nuclear membranes throughout the cell cycle. The ATR-mediated mechanical response occurs within the range of physiological forces, is reversible, and is independent of DNA damage signaling. ATR-defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown. We propose that mechanical forces derived from chromosome dynamics and torsional stress on nuclear membranes activate ATR to modulate nuclear envelope plasticity and chromatin association to the nuclear envelope, thus enabling cells to cope with the mechanical strain imposed by these molecular processes. (en)
Title	ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress (en)
skos:prefLabel	ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress (en)
skos:notation	RIV/68378050:_____/14:00436138!RIV15-AV0-68378050
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED0030/01/01)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Bártek, Jiří Košař, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	4462
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/14:00436138
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ATR; Mechanical Stress; cell cycle (en)
http://linked.open.../riv/klicoveSlovo	ATR cell cycle Mechanical Stress
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3A7607395267]
http://linked.open...i/riv/nazevZdroje	Cell
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	158
http://linked.open...iv/tvurceVysledku	Bartek, Jiří Košař, Martin Mazzanti, M. Mistrik, M. Kumar, A. Beznoussenko, G. V. Foiani, M. Garrè, M. Mironov, A. A. Parazolli, D. Scita, G. Shivashankar, G. V.
http://linked.open...ain/vavai/riv/wos	000340944300015
issn	0092-8674
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cell.2014.05.046

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