About: Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	RNA polymerase I (Pol I) transcription is essential for the cell cycle, growth and protein synthesis in eukaryotes. In the present study, we found that phosphatidylinositol 4,5-bisphosphate (PIP2) is a part of the protein complex on the active ribosomal promoter during transcription. PIP2 makes a complex with Pol I and the Pol I transcription factor UBF in the nucleolus. PIP2 depletion reduces Pol I transcription, which can be rescued by the addition of exogenous PIP2. In addition, PIP2 also binds directly to the pre-rRNA processing factor fibrillarin (Fib), and co-localizes with nascent transcripts in the nucleolus. PIP2 binding to UBF and Fib modulates their binding to DNA and RNA, respectively. In conclusion, PIP2 interacts with a subset of Pol I transcription machinery, and promotes Pol I transcription. RNA polymerase I (Pol I) transcription is essential for the cell cycle, growth and protein synthesis in eukaryotes. In the present study, we found that phosphatidylinositol 4,5-bisphosphate (PIP2) is a part of the protein complex on the active ribosomal promoter during transcription. PIP2 makes a complex with Pol I and the Pol I transcription factor UBF in the nucleolus. PIP2 depletion reduces Pol I transcription, which can be rescued by the addition of exogenous PIP2. In addition, PIP2 also binds directly to the pre-rRNA processing factor fibrillarin (Fib), and co-localizes with nascent transcripts in the nucleolus. PIP2 binding to UBF and Fib modulates their binding to DNA and RNA, respectively. In conclusion, PIP2 interacts with a subset of Pol I transcription machinery, and promotes Pol I transcription. (en)
Title	Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription (en)
skos:prefLabel	Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription (en)
skos:notation	RIV/68378050:_____/13:00423030!RIV14-GA0-68378050
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP305/11/2232), P(GD204/09/H084), P(LC06063), P(LC545)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Sobol, Margaryta Hozák, Pavel Dzijak, Rastislav Philimonenko, Vlada Yildirim, Sukriye Venit, Tomáš Castano, Enrique
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	81174
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/13:00423030
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nucleolus; transcription; PIP2; UBF; fibrillarin (en)
http://linked.open.../riv/klicoveSlovo	fibrillarin UBF transcription PIP2 nucleolus
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[57C36E837CBA]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Flurescence microscopy in biological and medical research Functional Organisation of the Cell Molecular biology of a differentiating cell Functions of myosin I and its binding partners in the cell nucleus
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	126
http://linked.open...iv/tvurceVysledku	Hozák, Pavel Sobol, Margaryta Castano, Enrique Dzijak, Rastislav Philimonenko, Vlada Venit, Tomáš Yildirim, Sukriye
http://linked.open...ain/vavai/riv/wos	000320705300018
issn	0021-9533
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1242/jcs.123661

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