About: The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies

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About: The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article. Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article. (en)
Title	The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies (en)
skos:prefLabel	The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies (en)
skos:notation	RIV/68378050:_____/10:00391344!RIV13-MZ0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(LC06044), P(NR8317), P(NR8930), P(NS10287), Z(AV0Z50520514), Z(MSM0021620806), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Anděra, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	285678
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00391344
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; cancer therapy; leukemia (en)
http://linked.open.../riv/klicoveSlovo	leukemia apoptosis cancer therapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E71AB2FCE7C3]
http://linked.open...i/riv/nazevZdroje	Current Pharmaceutical Design
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Experimental therapy of mantle cell lymphoma (MCL) Regulatory mechanisms of growth and apoptosis of primary leukemia progenitor/stem cells. Proteomic diagnosis of onkologic disaeses in gynecology Center of Molecular and Cellular Immunology Center for Experimental Hematology
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Anděra, Ladislav Pytlík, R. Klener, P. Živný, J.
http://linked.open...ain/vavai/riv/wos	000272773200003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	1381-6128
number of pages	23 (xsd:int)

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