| Attributes | Values |
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| rdf:type
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| Description
| - The effect of 13 flavonoid derivatives on paclitaxel transport was investigated in two human breast cancer cell lines, adriamycin-sensitive and adriamycin-resistant. Some derivatives proved to be efficient modulators of paclitaxel transport in P-gp highly expressing resistant human breast cancer cells. They also were more efficient than natural flavonoids. These agents could increase the efficiency of chemotherapy with paclitaxel in such resistant cells. However, care should be taken of the fact that drug transport in the P-gp non-expressing tumors may be influenced quite differently due to other transporters. Further studies are needed to investigate whether these derivatives are sufficiently potent to increase the effect of P-gp transported anticancer drugs in vivo.
- The effect of 13 flavonoid derivatives on paclitaxel transport was investigated in two human breast cancer cell lines, adriamycin-sensitive and adriamycin-resistant. Some derivatives proved to be efficient modulators of paclitaxel transport in P-gp highly expressing resistant human breast cancer cells. They also were more efficient than natural flavonoids. These agents could increase the efficiency of chemotherapy with paclitaxel in such resistant cells. However, care should be taken of the fact that drug transport in the P-gp non-expressing tumors may be influenced quite differently due to other transporters. Further studies are needed to investigate whether these derivatives are sufficiently potent to increase the effect of P-gp transported anticancer drugs in vivo. (en)
- Účinek 13 flavonoidových derivátů byl zkoumán u dvou buněčných linií lidského nádoru prsu odolných vůči adriamycinu a cilivých na tuto látku. Některé tyto deriváty napomáhaly transportu paxlitaxelu v rezistentních buňkách vysoce exprimujících P-gp. Byly také účinnější než přirozené flavonoidy. Tyto látky by mohly účinně napomáhat chemoterapii paclitaxelem u těchto rezistentních buněk. Je však třeba vzít v úvahu, že transport terapeutických látek v buňkách neexprimujících P-gp může být odlišný díky vlivu dalších přenašečů. Ke zjištění, zda tyto deriváty mají dostatečný vliv na zvýšení účinku protinádorových látek přenášených P-gp in vivo, je třeba dalších studií. (cs)
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| Title
| - Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?
- Modulace transportu paclitaxelu flavonoidovými deriváty v buňkách lidského nádoru prsu. Existuje vztah mezi vazebnou afinitou k NBD P-gp a modulací transportu? (cs)
- Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport? (en)
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| skos:prefLabel
| - Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?
- Modulace transportu paclitaxelu flavonoidovými deriváty v buňkách lidského nádoru prsu. Existuje vztah mezi vazebnou afinitou k NBD P-gp a modulací transportu? (cs)
- Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport? (en)
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| skos:notation
| - RIV/68378050:_____/06:00047757!RIV07-MZ0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA305/04/0403), P(NL7567), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/06:00047757
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - paclitaxel; multidrug resistance; flavonoid derivatives (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Bioorganic and Medicinal Chemistry Letters
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kovář, Jan
- Boumendjel, A.
- Ehrlichová, Marie
- Gut, I.
- Václavíková, R.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
| |
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