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| rdf:type
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| Description
| - Human processed pseudogenes are copies of cellular RNAs reverse transcribed and inserted into the nuclear genome by the enzymatic machinery of L1 (LINE1) non-LTR retrotransposons. Although it is generally accepted that germline expression is crucial for the heritable retroposition of cellular mRNAs, little is known about the influences of RNA stability, mRNA quality control and compartmentalization of translation on the retroposition of processed pseudogenes. We found that frequently retroposed human mRNAs are derived from stable transcripts with translation-competent functional reading frames that are resistant to nonsense-mediated RNA decay. They are preferentially translated on free cytoplasmic ribosomes and encode soluble proteins. Our results indicate that interactions between mRNAs and L1 proteins seem to occur at free cytoplasmic ribosomes.
- Human processed pseudogenes are copies of cellular RNAs reverse transcribed and inserted into the nuclear genome by the enzymatic machinery of L1 (LINE1) non-LTR retrotransposons. Although it is generally accepted that germline expression is crucial for the heritable retroposition of cellular mRNAs, little is known about the influences of RNA stability, mRNA quality control and compartmentalization of translation on the retroposition of processed pseudogenes. We found that frequently retroposed human mRNAs are derived from stable transcripts with translation-competent functional reading frames that are resistant to nonsense-mediated RNA decay. They are preferentially translated on free cytoplasmic ribosomes and encode soluble proteins. Our results indicate that interactions between mRNAs and L1 proteins seem to occur at free cytoplasmic ribosomes. (en)
- Lidské procesované pseudogeny jsou kopie buněčných RNA, které jsou reverzně přepsány a vloženy do jaderného genomu pomocí enzymatické mašinérie L1 (LINE1) non-LTR retrotranspozónů. Je obecně přijímáno, že exprese v germinální linii je zásadní pro děditelnou retropozici buněčné mRNA. Málo je však známo o vlivu RNA stability, kontrole kvality mRNA a kompartmentalizaci translace na retropozici procesovaných pseudogenů. V článku popisujeme, že často retrotransponované lidské mRNA jsou odvozeny od stabilních transkriptů s translačně funkčními čtecími rámci, které jsou rezistentní k mechanismu odstraňování nekódující mRNA. Jsou preferenčně překládány na volných cytoplasmatických ribozomech a kódují rozpustné proteiny. Naše výsledky naznačují, že k interakce mezi mRNA a L1 proteiny dochází na volných cytoplasmatických ribozómech. (cs)
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| Title
| - Retroposition of processed pseudogenes: the impact of RNA stability and translational control
- Retroposition of processed pseudogenes: the impact of RNA stability and translational control (en)
- Retropozice procesovaných pseudogenů: vliv stability RNA a translační kontroly (cs)
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| skos:prefLabel
| - Retroposition of processed pseudogenes: the impact of RNA stability and translational control
- Retroposition of processed pseudogenes: the impact of RNA stability and translational control (en)
- Retropozice procesovaných pseudogenů: vliv stability RNA a translační kontroly (cs)
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| skos:notation
| - RIV/68378050:_____/06:00029071!RIV06-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0520), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/06:00029071
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - processed pseudogenes; LINE1; retrotransposition (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Pačes, Jan
- Pačes, Václav
- Pavlíček, A.
- Jurka, J.
- Gentles, A. J.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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