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rdf:type
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Description
| - A vector for preparation of mouse polyomavirus capsid-like particles for transfer of foreign peptides or proteins into cells was constructed. Model pseudocapsids carrying EGFP fused with the C-terimal part of the VP3 minor protein (EGFP-VLPs) have been prepared and analysed for their ability to be internalised and processed by mouse cells and to activate mouse and human dendritic cells (DC) in vitro. EGFP-VLPs entered mouse epithelial cells, fibroblasts and human and mouse DC efficiently and were processed by both, lysosomes and proteasomes. Surprisingly, they did not induce upregulation of DC co-stimulation molecules or maturation markers in vitro; however, they did induce interleukin 12 secretion.
- A vector for preparation of mouse polyomavirus capsid-like particles for transfer of foreign peptides or proteins into cells was constructed. Model pseudocapsids carrying EGFP fused with the C-terimal part of the VP3 minor protein (EGFP-VLPs) have been prepared and analysed for their ability to be internalised and processed by mouse cells and to activate mouse and human dendritic cells (DC) in vitro. EGFP-VLPs entered mouse epithelial cells, fibroblasts and human and mouse DC efficiently and were processed by both, lysosomes and proteasomes. Surprisingly, they did not induce upregulation of DC co-stimulation molecules or maturation markers in vitro; however, they did induce interleukin 12 secretion. (en)
- Byl zkonstruován vektor myších polyomavirových kapsid-like částic pro přenos cizorodých peptidů a proteinů do buněk. Byly připraveny modelové pseudokapsidy nesoucí EGFP fuzovaný s C-terminální částí minoritního proteinu VP3 (EGFP-VPLs) a byla analyzována jejich schopnost internalizace a zpracování myšími buňkami jakož i schopnost aktivace myších a lidských dendritických buněk in vitro. EGFP-VPLs účinně pronikly do myších epiteliálních buněk, fibroblastů a lidských i myších dendritických buněk a byly upravovány jak lysozomy tak proteazomy. Překvapivě však neindukovaly stimulaci molekul a maturačních markerů in vitro, ale indukovaly sekreci interleukinu 12. (cs)
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Title
| - Polyomavirus EGFP-pseudocapsids:analysis of model particles for introduction of proteins and pepetides into mammalian cells
- Polyomavirus EGFP-pseudocapsids:analysis of model particles for introduction of proteins and pepetides into mammalian cells (en)
- Pseudokapsidy polyoma viru EGFP: analýza modelových partikulí pro vnášení proteinů a peptidů do savčích buněk (cs)
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skos:prefLabel
| - Polyomavirus EGFP-pseudocapsids:analysis of model particles for introduction of proteins and pepetides into mammalian cells
- Polyomavirus EGFP-pseudocapsids:analysis of model particles for introduction of proteins and pepetides into mammalian cells (en)
- Pseudokapsidy polyoma viru EGFP: analýza modelových partikulí pro vnášení proteinů a peptidů do savčích buněk (cs)
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skos:notation
| - RIV/68378050:_____/05:00026205!RIV06-AV0-68378050
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA204/03/0593), P(NC6957), Z(AV0Z50520514)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00026205
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - mouse polyomavirus; empty artificial virus-like particle; dendritic cell activation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Forstová, J.
- Holáň, Vladimír
- Štokrová, Jitka
- Marek, M.
- Spíšek, R.
- Frič, Jan
- Bouřa, E.
- Liebl, D.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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