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Description
| - Cells of transplantable MC38 colon carcinoma of C57BL/6 mice were adapted to growth in vitro, preserving their tumorigenicity. After transduction with a retroviral vector carrying murine interleukin 12 genes, stable transductant cells were obtained producing IL-12. After subcutaneous inoculation into syngeneic mice, the IL-12-modified cells showed reduced tumorigenicity as compared to parental cells. The obtained results show that the transduced cells could be used both as a model tumour for the study of anticancer immunity and/or as an adjuvant to cancer vaccines
- Cells of transplantable MC38 colon carcinoma of C57BL/6 mice were adapted to growth in vitro, preserving their tumorigenicity. After transduction with a retroviral vector carrying murine interleukin 12 genes, stable transductant cells were obtained producing IL-12. After subcutaneous inoculation into syngeneic mice, the IL-12-modified cells showed reduced tumorigenicity as compared to parental cells. The obtained results show that the transduced cells could be used both as a model tumour for the study of anticancer immunity and/or as an adjuvant to cancer vaccines (en)
- Buňky transplantovatelného karcinomu tlustého střeva MC38 myší C57BL/6 byly adaptovány pro růst in vitro bez ztráty tumorigenicity. Po transdukci retrovirovým vektorem nesoucím geny pro myší IL-12 byly získány stabilní transdukované buňky produkující IL-12. Po subkutánní inokulaci do syngenních myší vykazovaly buňky modifikované IL-12 ve srovnání s parentálními buňkami sníženou tumorigenicitu. Získané výsledky ukazují, že transdukované buňky bude možno využít jako modelový nádor pro studium protinádorové imunity a/nebo jako adjuvans pro nádorové vakcíny (cs)
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Title
| - Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes
- Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes (en)
- Ztráta tumorigenicity myší buněčné linie karcinomu tlustého střeva MC38/0 po transdukci retrovirovým vektorem nesoucím geny pro myší IL-12 (cs)
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skos:prefLabel
| - Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes
- Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes (en)
- Ztráta tumorigenicity myší buněčné linie karcinomu tlustého střeva MC38/0 po transdukci retrovirovým vektorem nesoucím geny pro myší IL-12 (cs)
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skos:notation
| - RIV/68378050:_____/04:00105307!RIV/2005/AV0/A23005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/04:00105307
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - MC38 murine colon carcinoma; IL-12 transduction; tumorigenicity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Indrová, Marie
- Pajtasz-Piasecka, E.
- Rossowska, J.
- DuĽ, D.
- Grabarczyk, P.
- Krawczenko, A.
- Mackiewicz, A.
- Szyda, A.
- Wysocki, P.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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