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rdf:type
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Description
| - Transformed phenotype of B cells infected with Theileria parva reverts on drug-induced parasite death, and the cured lymphocytes acquire a resting phenotype. Lymphocyte proliferation and activation of the transcription factor AP-1 are mediated by Src-family protein tyrosine kinases (present in membrane microdomains, GEMs) in a parasite-dependent fashion. Src-family PTKs are negatively regulated by PTK Csk complexed to tyrosine-photosphorylated transmembrane adapter protein PAG. Proliferation arrest led to a striking increase of PAG/Cbp in GEMs increased markedly, whereas PTK Hck accumulation in GEM fractions did not alter on growth arrest. Thus, Theileria-induced lymphocyte proliferation and permanent activation of Hck may stem from down-regulation of PAG/Cbp and the concomitant constitutive loss of the negative regulator Csk from the GEMs of transformed B cells.
- Transformed phenotype of B cells infected with Theileria parva reverts on drug-induced parasite death, and the cured lymphocytes acquire a resting phenotype. Lymphocyte proliferation and activation of the transcription factor AP-1 are mediated by Src-family protein tyrosine kinases (present in membrane microdomains, GEMs) in a parasite-dependent fashion. Src-family PTKs are negatively regulated by PTK Csk complexed to tyrosine-photosphorylated transmembrane adapter protein PAG. Proliferation arrest led to a striking increase of PAG/Cbp in GEMs increased markedly, whereas PTK Hck accumulation in GEM fractions did not alter on growth arrest. Thus, Theileria-induced lymphocyte proliferation and permanent activation of Hck may stem from down-regulation of PAG/Cbp and the concomitant constitutive loss of the negative regulator Csk from the GEMs of transformed B cells. (en)
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Title
| - Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes.
- Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. (en)
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skos:prefLabel
| - Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes.
- Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. (en)
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skos:notation
| - RIV/68378050:_____/03:23033105!RIV/2004/AV0/A23004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LN00A026), Z(AV0Z5052915)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/03:23033105
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Theileriosis; transformation; Csk (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Angelisová, Pavla
- Hořejší, Václav
- Werling, D.
- Baumgartner, M.
- Langsley, G.
- Mooney, N.
- Setterblad, N.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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