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rdf:type
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Description
| - The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous cytotrophoblast cells. HLA-G can inhibit the killing mediated by NK cells via interaction with the inhibitory NK cell receptor LIR-1. Comparison of the sequence of the HLA-G molecule to other class I MHC proteins revealed two unique cysteine residues 42 and 147. Mutating these cysteine residues resulted in a dramatic decrease in LIR-1 Ig binding. The mutated HLA-G transfectants were less effective in the inhibition of NK killing. The involvement of the cysteine residues in the formation of HLA-G protein oligomers was demonstrated. The cysteine residue 42 is critical for the expression of such complexes. These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells.
- The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous cytotrophoblast cells. HLA-G can inhibit the killing mediated by NK cells via interaction with the inhibitory NK cell receptor LIR-1. Comparison of the sequence of the HLA-G molecule to other class I MHC proteins revealed two unique cysteine residues 42 and 147. Mutating these cysteine residues resulted in a dramatic decrease in LIR-1 Ig binding. The mutated HLA-G transfectants were less effective in the inhibition of NK killing. The involvement of the cysteine residues in the formation of HLA-G protein oligomers was demonstrated. The cysteine residue 42 is critical for the expression of such complexes. These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells. (en)
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Title
| - Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.
- Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. (en)
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skos:prefLabel
| - Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.
- Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. (en)
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skos:notation
| - RIV/68378050:_____/03:23033071!RIV/2004/AV0/A23004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LN00A026), Z(AV0Z5052915)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/03:23033071
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - HLA-G; LIR-1; NK cells (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hořejší, Václav
- Mandelboim, O.
- Hanna, J.
- Achdout, H.
- Baniyash, M.
- Gazit, R.
- Goldman-Wohl, D.
- Gonen-Gross, T.
- Levy, O.
- Markel, G.
- Mizrahi, S.
- Yagel, S.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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