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Description
  • Cajalovo tělísko (CB) je jaderná struktura úzce svázaná s importem a biogenesí malých jaderných ribonukleotidových částic (snRNP). Testovali jsme, zda CB obsahuje vyzrálé snRNP a zda jeho integrita závisí na probíhajícím sestřihovém cyklu snRNP. Výsledky naznačují, že určité fáze tohoto cyklu probíhají v živých buňkách odděleně, přičemž ke skládání tri-snRNP dochází právě v CB. (cs)
  • The Cajal body (CB) is a nuclear structure closely associated with import and biogenesis of small nuclear ribonucleoprotein particles (snRNPs). Here, we tested whether CBs also contain mature snRNPs and whether CB integrity depends on the ongoing snRNP splicing cycle. The data show that particular phases of the spliceosome cycle are compartmentalized in living cells, with reassembly of the tri-snRNP occurring in CBs.
  • The Cajal body (CB) is a nuclear structure closely associated with import and biogenesis of small nuclear ribonucleoprotein particles (snRNPs). Here, we tested whether CBs also contain mature snRNPs and whether CB integrity depends on the ongoing snRNP splicing cycle. The data show that particular phases of the spliceosome cycle are compartmentalized in living cells, with reassembly of the tri-snRNP occurring in CBs. (en)
Title
  • Spliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies
  • Spliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies (en)
  • Sestřihové malé jaderné ribonukleoproteinové částice opakovně cyklují skrze Cajalova tělíska (cs)
skos:prefLabel
  • Spliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies
  • Spliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies (en)
  • Sestřihové malé jaderné ribonukleoproteinové částice opakovně cyklují skrze Cajalova tělíska (cs)
skos:notation
  • RIV/68378041:_____/08:00306873!RIV09-AV0-68378041
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA204/07/0133), P(GA301/05/0601), Z(AV0Z50390512), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 396532
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/08:00306873
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • snRNP; Cajal bodies; splicing (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [6BEA05356491]
http://linked.open...i/riv/nazevZdroje
  • Molecular Biology of the Cell
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 19
http://linked.open...iv/tvurceVysledku
  • Novotný, Ivan
  • Staněk, David
  • Blažíková, Michaela
  • Huranová, Martina
  • Přidalová, Jarmila
  • Neugebauer, K. M.
  • Sapra, A. K.
  • Wen, X.
http://linked.open...ain/vavai/riv/wos
  • 000259155200018
http://linked.open...n/vavai/riv/zamer
issn
  • 1059-1524
number of pages
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