About: TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells

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About: TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We demonstrated that TGF-beta1 suppresses the AhR-mediated gene expression through multiple mechanisms, involving inhibition of AhR expression and downregulation of nuclear AhR, via a SMAD4-dependent pathway. Our observations suggest that, in the context of prostate epithelium, TGF-beta1 signaling plays a dominant role in the crosstalk with AhR signaling pathway. We demonstrated that TGF-beta1 suppresses the AhR-mediated gene expression through multiple mechanisms, involving inhibition of AhR expression and downregulation of nuclear AhR, via a SMAD4-dependent pathway. Our observations suggest that, in the context of prostate epithelium, TGF-beta1 signaling plays a dominant role in the crosstalk with AhR signaling pathway. (en)
Title	TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells (en)
skos:prefLabel	TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells (en)
skos:notation	RIV/68081707:_____/12:00381596!RIV13-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(GA310/07/0961), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slabáková, Eva Pernicová, Zuzana Šeda, Václav Kozubík, Alois Vondráček, Jan Procházková, Jiřina Souček, Karel Kabátková, Markéta Staršíchová, Andrea
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	174171
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00381596
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transforming growth factor-beta; aryl hydrocarbon receptor ligand; prostate epithelial cells (en)
http://linked.open.../riv/klicoveSlovo	aryl hydrocarbon receptor ligand prostate epithelial cells transforming growth factor-beta
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4CCAA3BB4399]
http://linked.open...i/riv/nazevZdroje	Cellular Signalling
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of environmental pollutants in mechanisms regulating development of prostate carcinoma St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Kozubík, Alois Machala, M. Pernicová, Zuzana Procházková, Jiřina Pěnčíková, K. Slabáková, Eva Souček, Karel Vondráček, Jan Hrubá, E. Kabátková, Markéta Staršíchová, Andrea Šeda, Václav
http://linked.open...ain/vavai/riv/wos	000305712800022
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0898-6568
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cellsig.2012.04.008

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