About: Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the present study we used an organic extract of the urban dust standard reference material, SRM1649a, as a model mixture to study a range of toxic effects related to DNA damage and AhR activation. We found that this extract, as well as its neutral and polar fractions, were potent inducers of a range of AhR-mediated responses. Importantly, these toxic events occurred at doses one order of magnitude lower than induction of DNA damage. Our data suggested that more attention should be paid to the AhR-dependent nongenotoxic events elicited by urban air particulate matter constituents, especially polycyclic aromatic hydrocarbons and their derivatives. In the present study we used an organic extract of the urban dust standard reference material, SRM1649a, as a model mixture to study a range of toxic effects related to DNA damage and AhR activation. We found that this extract, as well as its neutral and polar fractions, were potent inducers of a range of AhR-mediated responses. Importantly, these toxic events occurred at doses one order of magnitude lower than induction of DNA damage. Our data suggested that more attention should be paid to the AhR-dependent nongenotoxic events elicited by urban air particulate matter constituents, especially polycyclic aromatic hydrocarbons and their derivatives. (en)
Title	Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons (en)
skos:prefLabel	Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons (en)
skos:notation	RIV/68081707:_____/11:00365816!RIV12-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/07/0961), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kozubík, Alois Vondráček, Jan Andrysík, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	184498
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00365816
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	urban air pollution; PAHs; AhR (en)
http://linked.open.../riv/klicoveSlovo	AhR PAHs urban air pollution
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CFC1994F6B5F]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of environmental pollutants in mechanisms regulating development of prostate carcinoma
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	714
http://linked.open...iv/tvurceVysledku	Andrysík, Zdeněk Baird, W. M. Ciganek, M. Kozubík, Alois Machala, M. Mahadevan, B. Marvanová, S. Neča, J. Pěnčíková, K. Topinka, Jan Vondráček, Jan
http://linked.open...ain/vavai/riv/wos	000294937700007
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Animal disease research, prevention and food chain protection
issn	0027-5107
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mrfmmm.2011.06.011

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