About: Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism     Goto   Sponge   Distinct   Permalink

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Description
  • V dané práci jsme odhalili, že kasein kináza 1 (CK1)delta/epsilon je nezbytná pro fosforylaci proteinu Dishevelled po přidání proteinů z nekanonické Wnt rodiny. Po přidání Wnt-řa, CK1epsilon váže Dv1 a následně ho fosforyluje. Naše data tak poprvé identifikují CK1 jako komponentu signální dráhy indukované proteinem Wnt-5a, která indukuje diferenciace dopaminergních neuronů. Navíc naše výsledky naznačují, že fosforylace Dvl kinázou CK1delta/epsilon je společným prvkem jak v kanonické, tak nekanonické Wnt dráze. (cs)
  • Using in vitro gain and loss of function approaches we reveal that casein kinase 1 (CK1)delta/epsilon is critical for dishevelled (Dv1) phosphorylation by non-canonical Wnts. We show that in response to Wnt-řa, CK1epsilon binds Dv1, which is subsequently phosphorylated. Our data identify CK1 as a component of Wnt-řa-induced signalling machinery that regulates dopaminergic differentiation, and suggests that CK1delta/epsilon-mediated phosphorylation of Dvl is a common step in both canonical and non-canonical Wnt signalling.
  • Using in vitro gain and loss of function approaches we reveal that casein kinase 1 (CK1)delta/epsilon is critical for dishevelled (Dv1) phosphorylation by non-canonical Wnts. We show that in response to Wnt-řa, CK1epsilon binds Dv1, which is subsequently phosphorylated. Our data identify CK1 as a component of Wnt-řa-induced signalling machinery that regulates dopaminergic differentiation, and suggests that CK1delta/epsilon-mediated phosphorylation of Dvl is a common step in both canonical and non-canonical Wnt signalling. (en)
Title
  • Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
  • Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism (en)
  • Wnt-5a indukuje fosforylaci Dishevelled a dopaminergní diferenciaci pomocí mechanismu závislém na CK1 (cs)
skos:prefLabel
  • Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
  • Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism (en)
  • Wnt-5a indukuje fosforylaci Dishevelled a dopaminergní diferenciaci pomocí mechanismu závislém na CK1 (cs)
skos:notation
  • RIV/68081707:_____/07:00082921!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany
  • 586;595
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 461358
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/07:00082921
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • casein kinase CK1delta/epsilon; Dishevelled; Wnt-5a (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [0ABC5568B63A]
http://linked.open...i/riv/nazevZdroje
  • Journal of Cell Science
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 120
http://linked.open...iv/tvurceVysledku
  • Bryja, Vítězslav
  • Schulte, G.
  • Arenas, E.
  • Grahn, A.
  • Rawal, N.
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9533
number of pages
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