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rdf:type
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Description
| - Samoštěpení HDV ribozymu je esenciální pro replikaci HDV, lidského patogenu jater. Katalyticky důležitý nukleotid C75 je podporován uspořádáním do trojlístku kolem vytěsněného G76. Ve všech dostupných krystalových strukturách je konformace G76 omezená stackingem s G76 sousedící molekuly. Za účelem zjistit, jestli tento krystalový kontakt vnáší nebo nevnáší strukturní chybu do katalytického jádra, jsme analyzovali cca 200 ns molekulově dynamických simulací. (cs)
- The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal structures, the conformation of G76 is restricted by stacking with G76 of a neighboring molecule. To test whether this crystal contact introduces a structural perturbation into a catalytic core, we have analyzed ~200 ns of molecular dynamics simulations.
- The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal structures, the conformation of G76 is restricted by stacking with G76 of a neighboring molecule. To test whether this crystal contact introduces a structural perturbation into a catalytic core, we have analyzed ~200 ns of molecular dynamics simulations. (en)
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Title
| - Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme
- Vliv vytěsněného nukleotidu na aktivitu štěpení a konformační dynamiku katalytického jádra hepatitis delta virus ribozymu (cs)
- Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme (en)
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skos:prefLabel
| - Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme
- Vliv vytěsněného nukleotidu na aktivitu štěpení a konformační dynamiku katalytického jádra hepatitis delta virus ribozymu (cs)
- Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme (en)
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skos:notation
| - RIV/68081707:_____/07:00081633!RIV07-AV0-68081707
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(LC512), Z(AV0Z50040507)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/07:00081633
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - conformational dynamics; hepatitis delta virus; molecular dynamics (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Šponer, Jiří
- Walter, N. G.
- Špačková, Naděžda
- Krasovská, Maryna V.
- Šefčíková, J.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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