About: MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	S využitím látky MK-886, inhibitoru proteinu aktivujícího 5-lipoxygenázu (5-LOX), byla studována role dráhy 5-LOX přeměny kyseliny arachidonové v diferenciaci indukované TNF-alpha u lidské buněčné leukemické linie HL-60. MK-886 posiloval zástavu buněčného cyklu a diferenciaci indukovanou TNF-alpha, ale tyto efekty jsou pravděpodobně nezávislé na inhibici 5-LOX, protože obecný inhibitor LOX, NDGA, neměl žádné účinky. Po kombinaci TNF-alpha a MK-886 byla významně potencována apoptóza, což částečně souviselo se změnami exprese proteinu Mc1-1. Signálování přes NF-ksíB nebo aktivace JNK nebyla MK-886 modulována. Tak, kromě apoptózy, MK-886 může zvyšovat i diferenciaci indukovanou TNF-alpha. (cs) We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-alpha; however, both effect were probably 5-LOX-independent, because a general LOX inhibitor, NDGA, had no effect. Apoptosis was significantly elevated after combined TNF-alpha and MK-886 treatment, which could be partially associated with changes of Mc1-1 protein expression. NF-ksíB signalling or activation of JNKs were not modulated by MK-886. Thus, in addition to apoptosis, MK-886 can enhance TNF-alpha-induced differentiation. We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-alpha; however, both effect were probably 5-LOX-independent, because a general LOX inhibitor, NDGA, had no effect. Apoptosis was significantly elevated after combined TNF-alpha and MK-886 treatment, which could be partially associated with changes of Mc1-1 protein expression. NF-ksíB signalling or activation of JNKs were not modulated by MK-886. Thus, in addition to apoptosis, MK-886 can enhance TNF-alpha-induced differentiation. (en)
Title	MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis (en) MK-886 zvyšuje diferenciaci a apoptózu indukovanou TNF-alpha (cs)
skos:prefLabel	MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis (en) MK-886 zvyšuje diferenciaci a apoptózu indukovanou TNF-alpha (cs)
skos:notation	RIV/68081707:_____/06:00040473!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	263;271
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/03/0766), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Štika, Jiří Kozubík, Alois Vondráček, Jan Hofmanová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	485998
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00040473
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell differentiation; leukaemia; HL-60 cells (en)
http://linked.open.../riv/klicoveSlovo	HL-60 cells cell differentiation leukaemia
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CB0A61DBE717]
http://linked.open...i/riv/nazevZdroje	Cancer letters
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of proliferation, differentiation and apoptosis of hemopoietic cells - interactions of cytokines, drugs and lipid nutrition compounds
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	237
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Vondráček, Jan Štika, Jiří Šimek, V.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0304-3835
number of pages	9 (xsd:int)

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