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Description
| - Byl popsán vliv vzniku monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu DNA a důsledky vyvolaných změn v termodynamické stabilitě modifikované DNA na její opravu složkami excisní nukleotidové opravy. (cs)
- Effects of adducts of [PtCl(NH3)(3)] Cl or chlorodiethylenetriamineplatinum(II) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes (15-bp) containing the single, site-specific monofunctional adduct at G-residues of the central sequences TGT/ACA or 5'-AGT/ 5'-ACT were prepared and analyzed by differential scanning calorimetry, temperature-dependent ultraviolet absorption and circular dichroism. The unfolding of the platinated duplexes was accompanied by relatively small unfavorable free energy terms. This destabilization was enthalpic in origin. On the other hand, a relatively large reduction of melting temperature (T-m) was observed as a consequence of the monofunctional adduct in the TGT sequence, whereas T-m due to the adduct in the AGT sequence was reduced only slightly.
- Effects of adducts of [PtCl(NH3)(3)] Cl or chlorodiethylenetriamineplatinum(II) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes (15-bp) containing the single, site-specific monofunctional adduct at G-residues of the central sequences TGT/ACA or 5'-AGT/ 5'-ACT were prepared and analyzed by differential scanning calorimetry, temperature-dependent ultraviolet absorption and circular dichroism. The unfolding of the platinated duplexes was accompanied by relatively small unfavorable free energy terms. This destabilization was enthalpic in origin. On the other hand, a relatively large reduction of melting temperature (T-m) was observed as a consequence of the monofunctional adduct in the TGT sequence, whereas T-m due to the adduct in the AGT sequence was reduced only slightly. (en)
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Title
| - Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes
- Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes (en)
- Vliv monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu a energetiku duplexů DNA (cs)
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skos:prefLabel
| - Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes
- Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes (en)
- Vliv monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu a energetiku duplexů DNA (cs)
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skos:notation
| - RIV/68081707:_____/05:00001331!RIV06-AV0-68081707
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA305/02/1552), P(GD204/03/H016), P(IAA5004101), P(KJB5004301), P(OC D20.004), Z(AV0Z50040507)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/05:00001331
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - DNA; platinum; cancer (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Kašpárková, Jana
- Hofr, Ctirad
- Bursová, Vendula
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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