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rdf:type
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Description
| - Publikovali jsme již, že numerická RNase A nemá žádné významné biologické aktivity, zatímco oligomery tohoto enzymu prokázaly pozoruhodné aspermatogenní a protinádorové působení. Rovněž bylo prokázáno, že chemická vazba nativní RNase A na PEG signifikatně zapůsobila antitumorově a aspermatogenně. V této práci jsme prokázali, že chemická vazba PEg a RNase A C-dimerem a trimerem snižuje aspermatogenní působení těchto komplexů. Na druhé straně se protinádorové působení na růst humánního UB 900518 melanomu rostoucího na athmických myších zvyšovalo. (cs)
- We have already shown that monomeric RNase A has no significant biological activity, whereas its oligomers (dimer to tetromer) show remarkable aspermatogenic and antitumour activities. Furthermore, conjugates prepared by chemical binding of native RNase A to polyethylene glycol (PEG) have shown a significant antitumour and aspermatogenic effects. In this work it was found that the chemical conjugation of PEG to the RNase A C-dimer, and to the RNase A trimers decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB 900518 amelanotic melanoma transplanted in athymic nusle mice.
- We have already shown that monomeric RNase A has no significant biological activity, whereas its oligomers (dimer to tetromer) show remarkable aspermatogenic and antitumour activities. Furthermore, conjugates prepared by chemical binding of native RNase A to polyethylene glycol (PEG) have shown a significant antitumour and aspermatogenic effects. In this work it was found that the chemical conjugation of PEG to the RNase A C-dimer, and to the RNase A trimers decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB 900518 amelanotic melanoma transplanted in athymic nusle mice. (en)
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Title
| - Some biological actions of PEG-conjugated RNase A oligomers
- Some biological actions of PEG-conjugated RNase A oligomers (en)
- PEGemi vázané RNase A oligomery a jejich některé biologické aktivity (cs)
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skos:prefLabel
| - Some biological actions of PEG-conjugated RNase A oligomers
- Some biological actions of PEG-conjugated RNase A oligomers (en)
- PEGemi vázané RNase A oligomery a jejich některé biologické aktivity (cs)
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skos:notation
| - RIV/67985904:_____/06:00040937!RIV07-AV0-67985904
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA523/04/0755), P(NR8233), Z(AV0Z50450515)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985904:_____/06:00040937
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - RNase A oligomers; polyethylene glycol conjugates; anti-tumour activity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Poučková, P.
- Matoušek, Josef
- Škvor, J.
- Slavík, Tomáš
- Souček, J.
- Gotte, G.
- Libonati, M.
- Vottariello, F.
- Laurents, D. V.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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