About: Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids     Goto   Sponge   Distinct   Permalink

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  • We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activated receptor (PPAR)-α target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3 PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders
  • We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activated receptor (PPAR)-α target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3 PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders (en)
Title
  • Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids
  • Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids (en)
skos:prefLabel
  • Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids
  • Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids (en)
skos:notation
  • RIV/67985823:_____/14:00435667!RIV15-GA0-67985823
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  • I, P(GA13-00871S)
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  • 11
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  • 16693
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  • RIV/67985823:_____/14:00435667
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  • fibroblast growth factor-21; long-chain n-3 polyunsaturated fatty acids (en)
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  • US - Spojené státy americké
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  • [CBE843CF170D]
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  • Lipids
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  • 49
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  • Kopecký, Jan
  • Medříková, Daša
  • Flachs, Pavel
  • Giralt, M.
  • Planavila, A.
  • Redondo-Angulo, I.
  • Villarroya, F.
  • Villarroya, J.
http://linked.open...ain/vavai/riv/wos
  • 000344151800001
issn
  • 0024-4201
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s11745-014-3948-x
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