About: Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension

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About: Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The objective of our in vivo study was to evaluate whether the impaired function of BKCa and/or KV channels is responsible for abnormal cAMP-induced vasodilatation in genetic hypertension. Under basal conditions, the vasodilator action of both K(+) channels was enhanced in SHR compared to WKY rats. However, the overall contribution of K(+) channels to cAMP-induced vasodilator mechanisms is insufficient in genetic hypertension since a concurrent activation of both K(+) channels by cAMP overproduction is necessary for the prevention of BP rise elicited by acute NO/cGMP deficiency in SHR. This might be caused by less effective activation of these K(+) channels by cAMP in SHR. In conclusion, K(+) channels seem to have higher activity in SHR, but their vasodilator action cannot match sufficiently the augmented vasoconstriction in this hypertensive strain The objective of our in vivo study was to evaluate whether the impaired function of BKCa and/or KV channels is responsible for abnormal cAMP-induced vasodilatation in genetic hypertension. Under basal conditions, the vasodilator action of both K(+) channels was enhanced in SHR compared to WKY rats. However, the overall contribution of K(+) channels to cAMP-induced vasodilator mechanisms is insufficient in genetic hypertension since a concurrent activation of both K(+) channels by cAMP overproduction is necessary for the prevention of BP rise elicited by acute NO/cGMP deficiency in SHR. This might be caused by less effective activation of these K(+) channels by cAMP in SHR. In conclusion, K(+) channels seem to have higher activity in SHR, but their vasodilator action cannot match sufficiently the augmented vasoconstriction in this hypertensive strain (en)
Title	Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension (en)
skos:prefLabel	Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension (en)
skos:notation	RIV/67985823:_____/14:00431288!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0510), P(GA305/09/0336), P(GAP304/12/0259), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zicha, Josef Pintérová, Mária Kuneš, Jaroslav Behuliak, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	22809
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00431288
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	isoprenaline; cAMP; potassium channels; calcium channels (en)
http://linked.open.../riv/klicoveSlovo	cAMP isoprenaline calcium channels potassium channels
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C4F0541E19EB]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Mutual interactions of various vasoactive systems, reactive oxygen species and G proteins in experimental hypertension Centre for cardiovascular research Mechanisms of antihypertensive action of high potassium intake in salt hypertension
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Kuneš, Jaroslav Pintérová, Mária Zicha, Josef Behuliak, Michal
http://linked.open...ain/vavai/riv/wos	000339879900001
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	11 (xsd:int)

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