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rdf:type
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Description
| - The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections
- The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections (en)
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Title
| - Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies
- Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies (en)
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skos:prefLabel
| - Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies
- Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies (en)
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skos:notation
| - RIV/67985823:_____/11:00369728!RIV12-AV0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA204/08/0718), P(LC06063), P(LC531), Z(AV0Z50110509), Z(AV0Z50200510), Z(MSM0021620858)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/11:00369728
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - CANDIDA-ALBICANS BIOFILMS; SACCHAROMYCES-CEREVISIAE; ABC TRANSPORTERS (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kubínová, Lucie
- Palková, Z.
- Váchová, Libuše
- Chernyavskiy, Oleksandr
- Hlaváček, Otakar
- Štěpánek, L.
- Šťovíček, V.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
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