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rdf:type
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Description
| - Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPKα2 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions
- Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPKα2 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions (en)
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Title
| - AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
- AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids (en)
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skos:prefLabel
| - AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
- AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids (en)
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skos:notation
| - RIV/67985823:_____/10:00349619!RIV11-GA0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0520), P(GAP301/10/1420), P(OC08007), Z(AV0Z50110509)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Mikšík, Ivan
- Kopecký, Jan
- Flachs, Pavel
- Hensler, Michal
- Macek Jílková, Zuzana
- Kůs, Vladimír
- Rossmeisl, Martin
- Kuda, Ondřej
- Janovská, Petra
- Medříková, Daša
- Jeleník, Tomáš
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/10:00349619
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - AMPK; n-3 LC-PUFA; insulin resistance (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kopecký, Jan
- Mikšík, Ivan
- Medříková, Daša
- Flachs, Pavel
- Hensler, Michal
- Macek Jílková, Zuzana
- Kůs, Vladimír
- Janovská, Petra
- Kuda, Ondřej
- Rossmeisl, Martin
- Baranowski, M.
- Jeleník, Tomáš
- Gorski, J.
- Hawley, S.
- Hébrard, S.
- Jensen, T. E.
- Viollet, B.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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