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Description
  • This review summarizes over 30 years of reserch on the molecular mechanisms of allosteric interactions of drugs with the receptor and for new allosteric modulators of muscarinic receptors with potential therapeutic use. Identification of positive modulators of acetylcholine binding and function that enhance neurotransmission and the discovery of highly selective allosteric modulators are mile-stones on the way to novel therapeutic agents for the treatment of schizophrenia, Alzheimer´s disease and other involving impaired cognitive function
  • This review summarizes over 30 years of reserch on the molecular mechanisms of allosteric interactions of drugs with the receptor and for new allosteric modulators of muscarinic receptors with potential therapeutic use. Identification of positive modulators of acetylcholine binding and function that enhance neurotransmission and the discovery of highly selective allosteric modulators are mile-stones on the way to novel therapeutic agents for the treatment of schizophrenia, Alzheimer´s disease and other involving impaired cognitive function (en)
Title
  • Allosteric Modulation of Muscarinic Acetylcholine Receptors
  • Allosteric Modulation of Muscarinic Acetylcholine Receptors (en)
skos:prefLabel
  • Allosteric Modulation of Muscarinic Acetylcholine Receptors
  • Allosteric Modulation of Muscarinic Acetylcholine Receptors (en)
skos:notation
  • RIV/67985823:_____/10:00348428!RIV11-GA0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/09/0681), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 245991
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/10:00348428
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • muscarinic acetylcholine receptors; allosteric modulation; Alzheimer´s disease (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [F23BBA25621C]
http://linked.open...i/riv/nazevZdroje
  • Pharmaceuticals
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 3
http://linked.open...iv/tvurceVysledku
  • El-Fakahany, E. E.
  • Jakubík, Jan
http://linked.open...n/vavai/riv/zamer
issn
  • 1424-8247
number of pages
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