About: A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk     Goto   Sponge   Distinct   Permalink

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  • Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF73)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein–Barr virus induced gene 2 (Ebi2), which lies at this locus and controls B lymphocyte migration is expressed in macrophages and regulates the IDIN. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D). These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D
  • Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF73)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein–Barr virus induced gene 2 (Ebi2), which lies at this locus and controls B lymphocyte migration is expressed in macrophages and regulates the IDIN. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D). These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D (en)
Title
  • A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
  • A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk (en)
skos:prefLabel
  • A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
  • A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk (en)
skos:notation
  • RIV/67985823:_____/10:00348257!RIV11-GA0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0520), P(GAP301/10/0290), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 7314
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 245040
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/10:00348257
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • IRF7 driven inflammatory network; Ebi2; type 1 diabetes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [FD848D2C430E]
http://linked.open...i/riv/nazevZdroje
  • Nature
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 467
http://linked.open...iv/tvurceVysledku
  • Bauerfeind, A.
  • Pravenec, Michal
  • Wallace, C.
  • Ziegler, A.
  • Cooper, J.
  • Bottolo, L.
  • Buchan, R.
  • Cook, S. A.
  • Hubner, N.
  • Lu, H.
  • Petretto, E.
  • Aitman, T. J.
  • Heinig, M.
  • Vingron, M.
  • Zeller, T.
  • Blankenberg, S.
  • Li, Y.
  • Samani, N. J.
  • Cambien, F.
  • Clayton, D.
  • Cyster, J. G.
  • Erdmann, J.
  • Goodall, A. H.
  • Gray, C. C.
  • Hengstenberg, C.
  • Hummel, O.
  • Langley, S. R.
  • Lee, Y. A.
  • Maouche, S.
  • Münzel, T.
  • Ouwehand, W. H.
  • Paskas, S.
  • Rice, C. M.
  • Rintisch, C.
  • Roider, H. G.
  • Rotival, M.
  • Saar, K.
  • Sarwar, R.
  • Schulz, H.
  • Schunkert, H.
  • Smyth, D. J.
  • Szymczak, S.
  • Tiret, L.
  • Todd, J. A.
http://linked.open...ain/vavai/riv/wos
  • 282090200043
http://linked.open...n/vavai/riv/zamer
issn
  • 0028-0836
number of pages
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