About: Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice     Goto   Sponge   Distinct   Permalink

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  • We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its onset. Our results indicate that functional pre- and postsynaptic cholinergic deficits are nor present in APPswe/PS1dE9 transgenic mice before 10 weeks of age, but develop along with beta-amyloid accumulation in the brain
  • We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its onset. Our results indicate that functional pre- and postsynaptic cholinergic deficits are nor present in APPswe/PS1dE9 transgenic mice before 10 weeks of age, but develop along with beta-amyloid accumulation in the brain (en)
Title
  • Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice
  • Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice (en)
skos:prefLabel
  • Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice
  • Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice (en)
skos:notation
  • RIV/67985823:_____/10:00345059!RIV11-MSM-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(IAA500110703), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 1
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http://linked.open...aciTvurceVysledku
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  • 259933
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/10:00345059
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Alzheimer´s disease; acetylcholine release; amyloid (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [28A37C628E56]
http://linked.open...i/riv/nazevZdroje
  • Neurobiology of Disease
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http://linked.open...vavai/riv/projekt
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  • 38
http://linked.open...iv/tvurceVysledku
  • Rudajev, Vladimír
  • Doležal, Vladimír
  • Tanila, H.
  • Machová, Eva
  • Smyčková, Helena
  • Koivisto, H.
http://linked.open...ain/vavai/riv/wos
  • 275812700004
http://linked.open...n/vavai/riv/zamer
issn
  • 0969-9961
number of pages
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