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Description
| - Cisplatin (cis-dichlorodiamineplatinum II) is a cytostatic used for treatment of tumors, including those of the brain. Molecular mechanisms of cell cycle effect of this drug are not entirely understood. In this study we compared the cell cycle changes induced by Cisplatin in tumor transformed rat C6 glioma cells and normal dividing rat brain cells, as represented by glial cells in cultures and germinative cells of the immature cerebellum exposed to the drug in situ. In normal cells, we found an early and profound alerting of the G1-phase checking point while changes in G2/M-phase compartment were much lower and found only in the cells exposed to Cisplatin in situ. In tumor transformed C6 glioma cells the G2/M checking point was found to be main, and/or, the only mechanism responding to Cisplatin. In addition, the number of G2/M blocked cells in C6 glioma cultures was remarkably increasing with time which indicates great intrapopulation heterogeneity in the efficiency of cell cycle control in these cel
- Cisplatin (cis-dichlorodiamineplatinum II) is a cytostatic used for treatment of tumors, including those of the brain. Molecular mechanisms of cell cycle effect of this drug are not entirely understood. In this study we compared the cell cycle changes induced by Cisplatin in tumor transformed rat C6 glioma cells and normal dividing rat brain cells, as represented by glial cells in cultures and germinative cells of the immature cerebellum exposed to the drug in situ. In normal cells, we found an early and profound alerting of the G1-phase checking point while changes in G2/M-phase compartment were much lower and found only in the cells exposed to Cisplatin in situ. In tumor transformed C6 glioma cells the G2/M checking point was found to be main, and/or, the only mechanism responding to Cisplatin. In addition, the number of G2/M blocked cells in C6 glioma cultures was remarkably increasing with time which indicates great intrapopulation heterogeneity in the efficiency of cell cycle control in these cel (en)
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Title
| - Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells.
- Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells. (en)
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skos:prefLabel
| - Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells.
- Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells. (en)
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skos:notation
| - RIV/67985823:_____/01:20010233!RIV/2003/AV0/A20003/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/01:20010233
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cell cycle; - cisplatin; - DNA content (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Acta Universitatis Purkynianae. Studia Biologica
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Lisá, Věra
- Mareš, Vladislav
- Ferrari, C.
- Šedo, A.
- Malík, Radek
- Mazzini, G.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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