About: Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells.

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells. Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cisplatin (cis-dichlorodiamineplatinum II) is a cytostatic used for treatment of tumors, including those of the brain. Molecular mechanisms of cell cycle effect of this drug are not entirely understood. In this study we compared the cell cycle changes induced by Cisplatin in tumor transformed rat C6 glioma cells and normal dividing rat brain cells, as represented by glial cells in cultures and germinative cells of the immature cerebellum exposed to the drug in situ. In normal cells, we found an early and profound alerting of the G1-phase checking point while changes in G2/M-phase compartment were much lower and found only in the cells exposed to Cisplatin in situ. In tumor transformed C6 glioma cells the G2/M checking point was found to be main, and/or, the only mechanism responding to Cisplatin. In addition, the number of G2/M blocked cells in C6 glioma cultures was remarkably increasing with time which indicates great intrapopulation heterogeneity in the efficiency of cell cycle control in these cel Cisplatin (cis-dichlorodiamineplatinum II) is a cytostatic used for treatment of tumors, including those of the brain. Molecular mechanisms of cell cycle effect of this drug are not entirely understood. In this study we compared the cell cycle changes induced by Cisplatin in tumor transformed rat C6 glioma cells and normal dividing rat brain cells, as represented by glial cells in cultures and germinative cells of the immature cerebellum exposed to the drug in situ. In normal cells, we found an early and profound alerting of the G1-phase checking point while changes in G2/M-phase compartment were much lower and found only in the cells exposed to Cisplatin in situ. In tumor transformed C6 glioma cells the G2/M checking point was found to be main, and/or, the only mechanism responding to Cisplatin. In addition, the number of G2/M blocked cells in C6 glioma cultures was remarkably increasing with time which indicates great intrapopulation heterogeneity in the efficiency of cell cycle control in these cel (en)
Title	Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells. Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells. (en)
skos:prefLabel	Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells. Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells. (en)
skos:notation	RIV/67985823:_____/01:20010233!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	23;29
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Mareš, Vladislav Lisá, Věra Malík, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	675022
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010233
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell cycle; - cisplatin; - DNA content (en)
http://linked.open.../riv/klicoveSlovo	cell cycle - DNA content - cisplatin
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D937691C9F7A]
http://linked.open...i/riv/nazevZdroje	Acta Universitatis Purkynianae. Studia Biologica
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Lisá, Věra Mareš, Vladislav Ferrari, C. Šedo, A. Malík, Radek Mazzini, G.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	1212-3137
number of pages	7 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 75 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software