About: Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations

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About: Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nucleophosmin (NPM1) mutations in exon 12 are the most common genetic alternation in cytogenetically normal AML (CN-AML). In this study, we have evaluated a novel, DNAbased real-time quantitative polymerase chain reaction (RQ-PCR) for the detection of three of the most commonly occurring mutations (A,B,D) and for six rare patient-specific mutation types, which represent 28% of all of the NPM1 mutations in our group of 25 CN-AML patients. Furthermore, the prognostic relevance of NPM1- based monitoring of minimal residual disease (MRD) in peripheral blood (PB), bone marrow (BM), and in specific cell subsets (CD341, CD342, CD34dim) of BM were evaluated. In 80% of the evaluable patients, a molecular relapse preceded a hematological relapse. Moreover, in this subset of patients, the molecular relapse occurred at a median of 97 days before the hematological relapse. Our analysis showed a strong correlation between BM and PB as well as a high copy number of mutated NPM1 in CD341 BM cells. Nucleophosmin (NPM1) mutations in exon 12 are the most common genetic alternation in cytogenetically normal AML (CN-AML). In this study, we have evaluated a novel, DNAbased real-time quantitative polymerase chain reaction (RQ-PCR) for the detection of three of the most commonly occurring mutations (A,B,D) and for six rare patient-specific mutation types, which represent 28% of all of the NPM1 mutations in our group of 25 CN-AML patients. Furthermore, the prognostic relevance of NPM1- based monitoring of minimal residual disease (MRD) in peripheral blood (PB), bone marrow (BM), and in specific cell subsets (CD341, CD342, CD34dim) of BM were evaluated. In 80% of the evaluable patients, a molecular relapse preceded a hematological relapse. Moreover, in this subset of patients, the molecular relapse occurred at a median of 97 days before the hematological relapse. Our analysis showed a strong correlation between BM and PB as well as a high copy number of mutated NPM1 in CD341 BM cells. (en)
Title	Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations (en)
skos:prefLabel	Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations (en)
skos:notation	RIV/65269705:_____/10:#0001006!RIV11-MZ0-65269705
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Palásek, Ivo Rázga, Filip Ráčil, Z. Dvořáková, Dana Lengerová, Martina Mayer, Jiří Ježíšková, Ivana Protivánková, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	272484
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/10:#0001006
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	minimal residual disease (en)
http://linked.open.../riv/klicoveSlovo	minimal residual disease
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[59EFB514215D]
http://linked.open...i/riv/nazevZdroje	American Journal of Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Dvořáková, Dana Lengerová, Martina Mayer, Jiří Rázga, Filip Ráčil, Zdeněk Ježíšková, Ivana Protivánková, Markéta Palásek, Ivo
http://linked.open...ain/vavai/riv/wos	000285165300004
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0361-8609
number of pages	4 (xsd:int)

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