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rdf:type
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Description
| - The present review summarizes the underlying biochemical and molecular mechanisms that can explain cardioprotective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their competition with arachidonic acid as a substrate of cyclooxygenase COX-2 and lipoxygenase 5-LOX, and modulation of the signaling pathways of the transcription factors peroxisome proliferator-activated receptor (PPAR), sterol-response element binding protein (SREBP) and nuclear factor jB (NF-jB). Consequences, namely decreased production of pro-inflammatory eicosanoids and cytokines, stimulation of b-oxidation, inhibition of fatty acid synthesis and down-regulation of the genes coding for enzymes of cholesterol synthesis and uptake are reviewed. Factors influencing responses of an organism to EPA/DHA intake are discussed and these include species, sex, dose and time interval of administration. Examples of food enrichment with EPA + DHAare presented under consideration of a low efficiency of conversion of a-linolenic acid to EPA (DHA).
- The present review summarizes the underlying biochemical and molecular mechanisms that can explain cardioprotective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their competition with arachidonic acid as a substrate of cyclooxygenase COX-2 and lipoxygenase 5-LOX, and modulation of the signaling pathways of the transcription factors peroxisome proliferator-activated receptor (PPAR), sterol-response element binding protein (SREBP) and nuclear factor jB (NF-jB). Consequences, namely decreased production of pro-inflammatory eicosanoids and cytokines, stimulation of b-oxidation, inhibition of fatty acid synthesis and down-regulation of the genes coding for enzymes of cholesterol synthesis and uptake are reviewed. Factors influencing responses of an organism to EPA/DHA intake are discussed and these include species, sex, dose and time interval of administration. Examples of food enrichment with EPA + DHAare presented under consideration of a low efficiency of conversion of a-linolenic acid to EPA (DHA). (en)
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Title
| - Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review
- Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review (en)
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skos:prefLabel
| - Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review
- Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review (en)
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skos:notation
| - RIV/62156489:43210/12:00184889!RIV13-MSM-43210___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/62156489:43210/12:00184889
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cholesterol; PUFAn-3; functional foods; SREBP; PPAR (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Functional Foods
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.jff.2011.10.008
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http://localhost/t...ganizacniJednotka
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