About: Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A number of 5-alkoxymethyluracil analogues were synthesized in order to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their corresponding nucleosides 2. All prepared compounds were submitted to cytotoxic activity testing against drug sensitive and drug resistant leukemia cells and solid tumor derived cell lines. In addition to this, the cytotoxic activity of 5-alkoxymethyluracil analogues 1,2 was compared with the previously published 5-[alkoxy(4-nitrophenyl)methyl]uracil analogues 3,4. Extensive structure-cytotoxic activity relationship studies are reported. A number of 5-alkoxymethyluracil analogues were synthesized in order to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their corresponding nucleosides 2. All prepared compounds were submitted to cytotoxic activity testing against drug sensitive and drug resistant leukemia cells and solid tumor derived cell lines. In addition to this, the cytotoxic activity of 5-alkoxymethyluracil analogues 1,2 was compared with the previously published 5-[alkoxy(4-nitrophenyl)methyl]uracil analogues 3,4. Extensive structure-cytotoxic activity relationship studies are reported. (en)
Title	Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study (en)
skos:prefLabel	Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study (en)
skos:notation	RIV/61989592:15310/11:33118318!RIV12-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0030/01/01), Z(MSM6198959216), Z(MSM6198959223)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hlaváč, Jan Brulíková, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	233924
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/11:33118318
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Nucleosides, Alkoxymethyluracils, Alkoxymethyluridines, Cytotoxic activity (en)
http://linked.open.../riv/klicoveSlovo	Alkoxymethyluracils Alkoxymethyluridines Nucleosides Cytotoxic activity
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[84BCDFDC6798]
http://linked.open...i/riv/nazevZdroje	Carbohydrate Research
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	346
http://linked.open...iv/tvurceVysledku	Džubák, Petr Hajdúch, Marián Hlaváč, Jan Brulíková, Lucie
http://linked.open...ain/vavai/riv/wos	000295754100011
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells Nové možnosti diagnostiky a imunomodulace u infekčních onemocnění a imunopatologických stavů
issn	0008-6215
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.carres.2011.07.026
http://localhost/t...ganizacniJednotka	15310

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